Copeptin Pancreatitis Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Association between copeptin level and severity of pancreatitis (according to Atlanta classification)
研究概览
简要总结
The purpose of this study is to investigate if there is an association between copeptin level in serum and the severity of pancreatitis and if copeptin can be used as a predictor for organ failure and pancreatic necrosis with or without superinfection.
详细描述
Acute pancreatitis may range from mild to severe disease with high mortality in case of infected pancreatic necrosis. Due to its rising incidence it remains an important healthcare problem in Europe and US. The assessment of the severity of pancreatitis is crucial for the further management and the prognosis. Several quite complex scores like Ranson or APACHE II scores has been used in the past with reasonable sensitivity for necrosis or superinfection as well as inflammation markers like c-reactive Protein.
Copeptin, the C-terminal part of antidiuretic hormone, is a relatively stable peptide in blood circulation. Several studies investigated Copeptin in the presence of Systemic Inflammatory Response Syndrome (SIRS) or sepsis, myocardial infarction, lower respiratory tract infection and cerebral stroke. Copeptin has shown to be a helpful prognostic marker in these diseases. The aim of this prospective study is to investigate whether Copeptin can be used to assess the severity of pancreatitis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosis of acute pancreatitis
- •written informed consent
- •inpatient treatment
排除标准
- •time interval between onset of abdominal symptoms and study inclusion >96h
- •patients unable to consent
结局指标
主要结局
Association between copeptin level and severity of pancreatitis (according to Atlanta classification)
时间窗: 48 hours
Copeptin level will be measured on admission into hospital and severity of pancreatitis will be classified according to the Atlanta criteria.
次要结局
- Comparison of copeptin with C reactive protein and procalcitonin in terms of assessing severity of pancreatitis(48 hours)
- Predictive accuracy of copeptin, C reactive Protein (CRP) and procalcitonin in terms of developing organ failure, necrosis and/or superinfection and mortality(Duration of hospitalisation)
- Determine whether change in copeptin level from day 0 to 2 is associated with organ failure, necrosis and/or superinfection(Duration of hospitalisation)