Timing of Preload Responsiveness in Sepsis and Septic Shock
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- The volume of fluid needed from the state of fluid responsiveness to fluid unresponsiveness
研究概览
简要总结
During acute circulatory failure, volume expansion does not always lead to a significant increase in cardiac output (fluid responsiveness). After initial resuscitation by rapid fluid administration, cardiac preload is no longer extremely low and only half of the patients respond to further volume expansion with the expected increase in cardiac output (fluid unresponsiveness). However, the time delay or the volume of fluid needed to be administered from the state of fluid responsiveness to fluid unresponsiveness is still not determined.
Objective To determine, in critically ill patients with acute circulatory failure,
- : the time and/or the volume of fluid needed from the state of fluid responsiveness to fluid unresponsiveness during septic shock.
- : determine the factors that influence this time and volume.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 ans
- •Onset of septic shock
排除标准
- •Planned to transfer the patient to another healthcare facility (inability to continue cardiac output measurements); urgent operation; Inability to measure the cardiac output.
结局指标
主要结局
The volume of fluid needed from the state of fluid responsiveness to fluid unresponsiveness
时间窗: 15-30 minutes during the fluid administration
If the fluid challenge is performed, the volume of each time for the fluid administration should be noted until the patient is no longer fluid-responsive, then the investigators can calculate the total amount of the fluid administrated.
The time delay from the state of fluid responsiveness to fluid unresponsiveness
时间窗: 60 minutes after the evaluation of fluid responsiveness
At the time of inclusion, the investigators use the tests available (fluid challenge, passive leg raising, end-expiratory occlusion test) to evaluate the presence of fluid responsiveness, and after one hour, the investigators repeat the test and to re-evaluate the presence of fluid responsiveness until the patient is no longer present the fluid responsiveness.
次要结局
- The risk factors for the volume of fluid needed from the state of fluid responsiveness to fluid(Through study completion, an average of 1 year)
- The risk factors for the time delay(Through study completion, an average of 1 year)
研究者
Xavier Monnet
Principal Investigator
Bicetre Hospital