Replacing With Whole Grains and Legumes Reduces Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Activities in Plasma and Peripheral Blood Mononuclear Cells in Patients With Prediabetes or Newly Diagnosed Type 2 Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Plasma Lp-PLA2 activity
研究概览
简要总结
We determined the effects of dietary intervention (replacement of refined rice with whole grains and legumes and a high intake of vegetables) on circulating Lp-PLA2 activity and enzyme activity in peripheral blood mononuclear cells (PBMCs) in patients with impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or newly-diagnosed type 2 diabetes.
详细描述
Ninety-nine patients with impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or newly-diagnosed type 2 diabetes were randomly assigned to either a control group (usual diet with refined rice) or the whole grain group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 39 Years 至 74 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects who were in in impaired fasting glucose (IFG, 100≤ fasting glucose <126 mg/dL)
- •or newly diagnosed type 2 diabetes (fasting glucose ≥126 mg/dL)
排除标准
- •current and/or past history of cardiovascular disease including angina
- •liver or kidney dysfunction
- •thyroid or pituitary disease
- •unstable weight loss/gain (≥2 kg) over the previous 12 months
- •pregnancy or lactation
- •taking medications or supplements
研究组 & 干预措施
Whole grains and legumes
干预措施: Dietary intervention-whole grains and legumes (Dietary Supplement)
Refined rice
干预措施: Dietary intervention-Refined rice (Dietary Supplement)
结局指标
主要结局
Plasma Lp-PLA2 activity
时间窗: Change from baseline in Lp-PLA2 at 12 weeks
次要结局
- PBMC Lp-PLA2 activity(Change from baseline in PBMC Lp-PLA2 at 12 weeks)