NL-OMON56529尚未招募不适用
Spinal Muscular Atrophy Randomized Controlled Trial on Cough Techniques (Patient tailored airway clearance in patients with Spinal Muscular Atrophy: a randomized controlled trial comparing air stacking and mechanical insufflation-exsufflation.) - SMARCT
niversitair Medisch Centrum Utrecht0 个研究点目标入组 46 人开始时间: 待定最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 46
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 2 至 64（—）
入选标准
- •Patients with Spinal Muscular Atrophy
- •Peak expiratory cough flow < 270 L/min if >= 10 years or PECF <200 L/min in
- •patients 8-9 years
- •Patients from 8 years of age.
- •Able to perform spirometry
排除标准
- •- Severe gastroesophageal reflux with risk of aspiration despite treatment
- •- Severe esophageal and gastric varices
- •- Recent pneumothorax (< 6 weeks)
- •- Recent barotrauma
- •- Emphysema, bullae
- •- Tracheo-oesphageal fistula
- •- Severe facial deformity
- •- Tracheostomy
- •- Patient or legal representative unable to speak and understand Dutch or
- •- RTI in 6 weeks prior to inclusion. If the patient suffers from a RTI in the
- •period between screening and baseline measurements, it is not required to
- •repeat the screening.
- •- Respiratory muscle training initiated < 6 weeks prior to inclusion
- •-Daily use of mechanical insufflation-exsufflation.Patients who used MI-E
- •temporarily during a respiratory tract infection in the past are eligible for
- •inclusion.*
研究者
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