The Impact of Hybrid-type High-intensity Interval Training on Vitamin D Metabolism in Adults With Overweight/Obesity
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Change in calcium concentration
研究概览
简要总结
The prevalence of Vitamin D deficiency is significantly higher in adults with overweight/obesity compared to those with normal body mass index (BMI). The "entrapment" of Vitamin D in adipose tissue due to impaired lipolytic stimulation and/or adipose tissue dysfunction has been proposed as the driving mechanism. Exercise training has been proposed as a promising strategy to increase mobilization of Vitamin D from adipose tissue, given its well described role in stimulating lipolysis. Indeed, a recent study revealed that participation in moderate-intensity cardiovascular type exercise over winter can mitigate the decline in 25-hydroxyvitamin D [25(OH)D] in adults with overweight/obesity, independent of weight loss. The aim of this study is to investigate the impact of hybrid-type high-intensity interval training over winter on vitamin D metabolism, in adults with overweight/obesity.
详细描述
Thirty adults with overweight/obesity (both males and females) who will meet the inclusion criteria will be randomly assigned to either an Exercise group (n=15) or a Control group (n=15). The Exercise group will participate in three hybrid-type high-intensity interval training sessions per week over a 12-week period, while receiving a balanced diet. The Control group will receive a balanced diet but will not participate in exercise training. Both groups will provide a resting blood sample and undergo assessment of their body composition (via bioelectrical impedance analysis), daily dietary intake (via dietary recalls) and physical activity level (via accelerometry) at baseline (prior to intervention), 6 weeks and 12 weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI = 25-35 kg/m2
- •Absence of musculoskeletal injuries
- •Absence of chronic health-related complications
- •Non-smokers
排除标准
- •Consumption of Vitamin D supplements
- •Consumption of anti-inflammatory drugs, statins and/or steroids
研究组 & 干预措施
Exercise group
Exercise group will participate in three hybrid-type high-intensity interval training sessions per week over a 12-week period, while receiving a balanced diet
干预措施: Exercise training (Other)
Control group
Control group will receive a balanced diet but will not participate in exercise training
干预措施: Control (Other)
结局指标
主要结局
Change in calcium concentration
时间窗: At baseline, 6 weeks and 12 weeks
Calcium concentration will be determined in serum
Change in albumin concentration
时间窗: At baseline, 6 weeks and 12 weeks
Albumin concentration will be determined in serum
Change in 25-hydroxyvitamin D concentration
时间窗: At baseline, 6 weeks and 12 weeks
25-OH-VD will be quantitatively determined in serum
Change in aspartate aminotransferase (SGOT) concentration
时间窗: At baseline, 6 weeks and 12 weeks
SGOT concentration will be determined in serum on a Clinical Chemistry analyzer
Change in alanine aminotransferase (SGPT) concentration
时间窗: At baseline, 6 weeks and 12 weeks
SGPT concentration will be determined in serum on a Clinical Chemistry analyzer
Change in plasma Vitamin D binding protein concentration
时间窗: At baseline, 6 weeks and 12 weeks
Vitamin D binding protein concentration will be determined in plasma
Change in calcium concentration
时间窗: At baseline, 6 weeks and 12 weeks
Calcium concentration will be determined in serum
Change in albumin concentration
时间窗: At baseline, 6 weeks and 12 weeks
Albumin concentration will be determined in serum
Change in gamma-glutamyl transferase (γ-GT) concentration
时间窗: At baseline, 6 weeks and 12 weeks
γ-GT concentration will be determined in serum on a Clinical Chemistry analyzer
次要结局
- Change in body composition(At baseline, 6 weeks and 12 weeks)
- Change in dietary intake(At baseline, 6 weeks and 12 weeks)
- Change in physical activity level(At baseline, 6 weeks and 12 weeks)
- Change in oxidized glutathione concentration(At baseline, 6 weeks and 12 weeks)
- Change in body composition(At baseline, 6 weeks and 12 weeks)
- Change in reduced glutathione concentration(At baseline, 6 weeks and 12 weeks)
- Change in physical activity level(At baseline, 6 weeks and 12 weeks)
- Change in dietary intake(At baseline, 6 weeks and 12 weeks)
研究者
Dimitrios Draganidis
Assistant Professor
University of Thessaly