Unpacking the "Mind" and "Body" Pathways of the Antidepressant Effect of Qigong in Older Adults: A Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 106
- 试验地点
- 1
- 主要终点
- Depressive symptoms
研究概览
简要总结
The goals of the study are to explore the neurobiological mechanisms and cognitive benefits of qigong in older adults. The main research questions are:
- Does 12-week qigong training lead to significant enhancement in serum adiponectin, serum BDNF and significant reduction in salivary cortisol?
- Does 12-week qigong training bring significant improvement in global cognitive function?
Participants are older adults aged 60 or above. They were randomly assigned to qigong training, mindfulness training, physical exercise training, or wait-list which all last for 12 weeks. Their changes before and after the 12-week period in depressive symptoms, neurobiological markers, and cognitive functions are assessed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •60 years or older;
- •With mild or severer levels of depressive symptoms as indicated by the Geriatric Depression Scale (GDS-8) scores of 5 or above, or Depression Anxiety and Stress Scale-21 (DASS-21) depression subscale scores of 4 or above
- •Self-identified as physically stable and without life-threatening diseases.
排除标准
- •With a history of practicing or receiving training of any form of mind-body or regular exercises (including tai chi, yoga, and qigong, or regular physical activity > 3 times/week) during the month prior to study enrollment
- •Having changed medications or the dose of medications prescribed for their health condition in the month prior to study enrollment
- •With severe cognitive or language impairment as defined as a score of less than 21 on Montreal Cognitive Assessment (MoCA-5min)
- •Undergoing electroconvulsive therapy, psychotherapy, or psychoeducation for a psychological or psychiatric condition
- •Unable to demonstrate satisfactory standing balance.
研究组 & 干预措施
Qigong
12-week training of Baduanjin (or named Eight-Section Brocades), with two sessions per week. Each session lasts for 60 min.
干预措施: Qigong (Behavioral)
Mindfulness-based Training
12-week training of mindfulness-based breathing, walking, and stretching practices, with two sessions per week. Each session lasts for 60 min.
干预措施: Mindfulness-based training (Behavioral)
Low-to-moderate Intensity Physical Exercise
12-week training of stretching, flexibility exercise, and balance exercise, with two sessions per week. Each session lasts for 60 min.
干预措施: Low-to-moderate intensity physical exercise (Behavioral)
Waitlist
No training while the other three group are receiving training. Participants of this group are allowed to have Qigong, Mindfulness-based Training, or Low-to-moderate Intensity Physical Exercise after they complete all the assessments.
结局指标
主要结局
Depressive symptoms
时间窗: Baseline and post-intervention (12 weeks after baseline)
The eight-item Patient Health Questionnaire
Global cognitive function
时间窗: Baseline and post-intervention (12 weeks after baseline)
Montreal Cognitive Assessment
次要结局
- Inhibitory control(Baseline and post-intervention (12 weeks after baseline))
- ERP N2 amplitude(Baseline and post-intervention (12 weeks after baseline))
- ERP P3 amplitude(Baseline and post-intervention (12 weeks after baseline))
- Serum adiponectin(Baseline and post-intervention (12 weeks after baseline))
- Serum BDNF(Baseline and post-intervention (12 weeks after baseline))
- Salivary cortisol(Baseline and post-intervention (12 weeks after baseline))
- Attention(Baseline and post-intervention (12 weeks after baseline))
- Working memory(Baseline and post-intervention (12 weeks after baseline))
研究者
TSANG Hector Wing-Hong
Professor
The Hong Kong Polytechnic University