Investigation of the brain pathophysiology of addiction disorder using cerebral glucose metabolism and brain network analysis and evaluation of the treatment effect of neuromodulation

The Catholic University of Korea, Incheon St. Mary's Hospital0 个研究点目标入组 80 人开始时间: 待定最近更新: 2019年7月17日

试验速览

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•[Alcohol use disorder group]
•(a) Diagnosed with alcohol use disorder based on the Diagnostic and Statistical Manual of Mental Disorders-5 and taking standard medication, and alcohol abstinence status will be considered.
•(b) Adult men and women aged 20 to 60 years
•[Problematic drinking group]
•(a) More than 4 standard drinks (SD) for one occasion or more than 14 SD for one week (men) / More than 3 SD for one occasion or more than 7 SD for one week (women) or scores of 8 or more on Alcohol Use Disorders Identification Test (AUDIT) for men / scores of 6 of more on AUDIT for women
•(b) Adult men and women aged 20 to 60 years
•[Normal control group]
•(a) Adult men and women aged 20 to 60 years

•Exclusion criteria
•(a) Have major medical, neurological, or psychiatric illnesses
•(b) Pregnant, lactation, or have a pregnancy plan
•(c) Not compatible for MRI and PET-CT (internal metal and medical devices, claustrophobia, etc.)
•(d) History of seizures
•(e) Problems with stimulation electrodes due to deformity of the scalp, inflammation reaction or other dermatological problems
•(f) History of cancer in the past three years
•(g) Surgery for brain vessels such as brain surgery or carotid surgery
•(h) Dyspnea when sitting still
•(i) Loss of consciousness for more than one hour due to other causes other than general anesthesia
•(j) Have been hospitalized for a head injury

发起方

The Catholic University of Korea, Incheon St. Mary's Hospital