Study on the Clinical Characteristics of Interstitial Lung Disease and Obstructive Sleep Apnea
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- imaging changes and ROSE and NGS in patients
研究概览
简要总结
Clinically, all patients with interstitial lung disease(ILD) were observed, and relevant clinical data were collected. Bronchoscopic specimens were collected according to the condition of the enrolled patients, and the rapid on site evaluation(ROSE) was evaluated, combined with the metagenomic next generation sequencing(mNGS) results of these patients. To observe the etiology and biological characteristics of exacerbation in patients with interstitial lung disease.
All patients undergo polysomnography (PSG) and drug-induced sleep endoscopy(DISE). The biological specimens was obtained for molecular biology or other tests.We detected ZNF331, Claudin1, Claudin2, Claudin3, Claudin4, and IL22 as biomarkers to differentiate the diagnostic efficiency of OSA in ILD, ILD+OSA, OSA, and Ctrl groups, respectively
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •over 18 years old and under 80 years old.
- •Clinical diagnosis of interstitial lung disease or obstructive respiratory sleep apnea syndrome.
- •Patient is conscious and capable of signing informed consent.
- •The patient may wear a polysomnograph.
排除标准
- •malignant tumors.
- •severe heart failure.
- •autoimmune diseases.
- •pulmonary embolism, and end-stage chronic obstructive pulmonary disease.
- •Patients with mental illnesscannot sign informed consent on their own.
研究组 & 干预措施
ILD with OSA group
ILD patient diagnosed with OSA by PSG. Bronchoscopy was performed to obtain alveolar lavage fluid in ILD patients and lung tissue was obtained for ROSE and mNGS in appropriate patients
干预措施: The relationship between imaging and ROSE and NGS (Diagnostic Test)
ILD without OSA
ILD patients excluded OSA through PSG. Bronchoscopy was performed to obtain alveolar lavage fluid in ILD patients and lung tissue was obtained for ROSE and mNGS in appropriate patients
干预措施: The relationship between imaging and ROSE and NGS (Diagnostic Test)
结局指标
主要结局
imaging changes and ROSE and NGS in patients
时间窗: 2Day
Relationship between imaging changes and ROSE and NGS in patients with interstitial lung disease
次要结局
- Severity and biological examination of OSA patients(2Day)
研究者
Dan Liu
Master of Medicine, attending physician
Tianjin Medical University General Hospital