Long Non-coding RNA: PCGEM1 as a Potential Marker for Tumorigenesis in Breast Cancer
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 90
- 主要终点
- Relative expression level of PCGEM1 marker in breast cancer tissue and blood sample
研究概览
简要总结
This study examines certain molecular markers in breast cancer using blood and tissue samples from routine diagnostic biopsies. No extra procedures will be performed on patients. The goal is to improve understanding of disease mechanisms and identify potential targets for treatment
详细描述
This is an observational, case-control study designed to evaluate the expression of lncRNA PCGEM1 and its association with related molecular pathways, including RhoA, TRIAP1, and ferroptosis, in breast cancer patients. The study will include patients diagnosed with breast cancer and a matched control group.
No intervention will be performed as part of this study. Tissue samples will be obtained from routine diagnostic biopsies that are already indicated as part of standard clinical care, with no additional procedures carried out for research purposes.
Collected tissue samples will be processed for RNA extraction and subsequent molecular analysis to assess gene expression levels. The results will be analyzed to explore the potential role of PCGEM1 in tumor progression and its correlation with selected molecular pathways.
The findings of this study may contribute to a better understanding of breast cancer biology and help identify potential biomarkers or therapeutic targets.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Age: 18 years and older.
- •Newly diagnosed patients with histopathological confirmation of the diagnosis of breast cancer at any stage.
排除标准
- •Presence of any chronic diseases.
- •Previous history of breast cancer or other malignancies.
- •Evidence of distant metastasis at the time of diagnosis.
- •Prior treatment with chemotherapy or radiotherapy.
- •Incomplete clinical or laboratory data.
研究组 & 干预措施
female breast cancer patients and matched control - no intervention
干预措施: No Biologics (Device)
结局指标
主要结局
Relative expression level of PCGEM1 marker in breast cancer tissue and blood sample
时间窗: at base line
This outcome measures the relative expression level of PCGEM1 in breast cancer tissue and blood samples compared to control using quantitative real-time PCR (qRT-PCR). The results will be correlated with clinicopathological parameters.
次要结局
未报告次要终点
研究者
Rehab Mostafa Thabet Ahmed
assistant lecturer
Assiut University