Comparison of Emergence and Recovery Time, and Evaluation of Oxygenation During One-lung Ventilation With Desflurane and Propofol Anesthesia in Lung Surgery- A Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Oxygenation
研究概览
简要总结
Which is more adequate general anesthetic agent, desflurane or propofol, for emergence and recovery time, and perioperative oxygenation in lung resection surgery?
详细描述
The investigators plan to investigate the effects of desflurane on oxygenation (prevention of HPV) of OLV compare with propofol which is used in general anesthesia for lung resection.
Transesophageal echocardiography (TEE) wiill be used to measure pulmonary blood flow during surgery visible and successively. To confirm the effect of HPV by measuring the change in pulmonary blood flow. The correlation between the blood oxygen concentration and attenuation of blood flow will be investigated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients agree to participate in the study
- •Patients undergoing lung cancer surgery requiring one-lung ventilation.
- •American Society of Anesthesiologists Physical Status Class 1 or 2
排除标准
- •Patients with any of the following will be excluded from lung cancer patients.
- •New York Heart Association Classification more than 2
- •Respiratory dysfunction Vital Capacity or percent predicted Forced expiratory volume in one second is less than 50 %
- •Pulmonary hypertension with mean pulmonary arterial pressure more than 30 mmHg
- •Coagulation dysfunction
- •The administration of steroids and immunosuppressive agents within 3 months prior to surgery
- •Infection with active inflammation
- •Pneumonectomy patients
- •Cases of epidural anesthesia is contraindicated
研究组 & 干预措施
Desflurane
Desflurane group: this group of patients receives desflurane as the main anesthetic agent in addition to remifentanil infusion at 0.1~0.3 mcg/kg/min during one-lung anesthesia. Bispectral index will be maintained between 45 and 50. Arterial blood gases and pulmonary blood flow by using tansesphageal echocardiogrphy will be measured.
干预措施: desflurane (Drug)
Propofol
Propofol group: this group of patients receives propofol as the main anesthetic agent in addition to remifentanil infusion at the rate of 0.1~0.3 mcg./g/min during one-lung anesthesia. Bispectral index will be maintained between 45 and 50. Arterial blood gases and pulmonary blood flow by using tansesphageal echocardiogrphy will be measured.
干预措施: propofol (Drug)
结局指标
主要结局
Oxygenation
时间窗: prior to surgery to one-hour after extubation
Arterial blood gases are monitored.Pulmonary blood flow is measured using transesophageal echocardiogram.
次要结局
- Quality of Consiousness(after extubation)
- Postoperative Nausea and Vomiting(on the postoperative day 1)
- Rapidity of Emergence From Anesthesia(one minute after cessation of anethetic agents to one hour after extubation)