The Role of Expectations in the Pharmacological Treatment of Depression - An Experimental Investigation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 94
- 试验地点
- 4
- 主要终点
- Sadness
研究概览
简要总结
The study aimes at identifying whether positive expectations have an impact on the way depressive participants experience emotions in the form of sadness.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •major depression (mild to moderate)
- •fluent in German language
排除标准
- •bipolar disorder, psychotic disorder, substance dependence
- •cardiovascular disease, severe kidney or liver disease, epilepsy
- •change of psychotropic medication intake within the last four weeks
- •allergic to capsaicin
- •allergic to sesame oil
- •students in medicine, pharmacy, or psychology in their third year or older
- •completed studies in medicine, pharmacy or psychology
研究组 & 干预措施
Positive placebo group
Participants receive a placebo nasal spray. However, they are told that it protects from experiencing negative emotions. Participants watch a film sequence that is supposed to induce sadness.
干预措施: Placebo nasal spray (Other)
Positive placebo group
Participants receive a placebo nasal spray. However, they are told that it protects from experiencing negative emotions. Participants watch a film sequence that is supposed to induce sadness.
干预措施: Film sequence (Other)
Placebo control group
Participants receive a placebo nasal spray and are told that it is a placebo. Participants watch a film sequence that is supposed to induce sadness.
干预措施: Placebo nasal spray (Other)
Placebo control group
Participants receive a placebo nasal spray and are told that it is a placebo. Participants watch a film sequence that is supposed to induce sadness.
干预措施: Film sequence (Other)
No-treatment control group
Participants do not receive the nasal spray. Participants watch a film sequence that is supposed to induce sadness.
干预措施: Film sequence (Other)
结局指标
主要结局
Sadness
时间窗: Directly after watching the film sequence, no follow-up assessments
Items of PANAS-X
次要结局
未报告次要终点
研究者
Winfried Rief
Professor Dr.
Philipps University Marburg Medical Center