NCT01344928Unknown不适用
The Effects of Short-time High-intensity Interval Training on Tissue Glucose and Fat Metabolism in Healthy Subjects and Patients With Type 2 Diabetes
适应症
干预措施
试验速览
- 阶段
- 不适用
- 试验地点
- 1
研究概览
简要总结
The objectives of this study are to investigate the effects of short-time high-intensity interval training on tissue glucose and fat metabolism in healthy lean subjects and type 2 diabetic patients using modern and noninvasive imaging methods positron emission tomography (PET), magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS).
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 40 Years 至 55 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •The healthy patients
- •BMI 18.5-30
- •Fasting plasma glucose less than 6.1 mmol/l
- •Normal glucose tolerance test (OGTT)
- •The type 2 diabetic patients:
- •Age-, sex-, and BMI-matched with the study subjects in the phase 1
- •In a good treatment balance
- •Glycated haemoglobin (HbA1c) less than 7.5 mmol/l
- •Two hours glucose value in oral glucose tolerance test (OGTT) less than 10.0 mmol/l
排除标准
- •The healthy patients
- •Blood pressure > 140/90 mmHg
- •Any chronic disease
- •Any chronic medical defect or injury which hinder/interfere everyday life
- •History of anorexia nervosa or bulimia
- •History of rest or exercise-induced asthma
- •Previous use of anabolic steroids, additives or any other substrates
- •Smoking of tobacco, taking of snuffs, or use of narcotics.
- •Significant use of alcohol
- •Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
- •Presence of any ferromagnetic objects that would make MR imaging contraindicated
- •Current or history of regular and systematic exercise training
- •VO2max >40 ml/min/kg
- •The type 2 diabetic patients:
- •Any other chronic disease than diabetes
- •Blood pressure > 140/90 mmHg
- •Any chronic medical defect or injury which hinder/interfere everyday life
- •History of anorexia nervosa or bulimia
- •History of rest or exercise-induced asthma
- •Smoking of tobacco, taking of snuffs, or use of narcotics.
- •Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
- •Presence of any ferromagnetic objects that would make MRI imaging contraindicated
- •Current or history of regular and systematic exercise training
- •VO2max >40 ml/ min/kg
研究组 & 干预措施
HIT training
Experimental
干预措施: HIT exercise intervention (Behavioral)
Aerobic exercise training
Active Comparator
干预措施: Aerobic exercise intervention (Behavioral)
研究者
研究点 (1)
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