Influence of CPB and Mini CPB to the Absorption of the Metoprolol After CABG
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 45
- 试验地点
- 1
- 主要终点
- absorbtion of the metoprolol
研究概览
简要总结
Influence of perfusion, miniperfusion and off pump coronary artery bypass grafting to the absorbtion of metoprolol postoperatively, hypothesis in that miniperfusion and off pump surgery does not decrease absorbtion of the metoprolol compared to conventional pefusion.
详细描述
Influence of perfusion, miniperfusion and off pump coronary artery bypass grafting to the absorbtion of metoprolol postoperatively, hypothesis in that miniperfusion and off pump surgery does not decrease absorbtion of the metoprolol compared to conventional pefusion.
Blood samples for concentration of metoprolol are taken preoperaively, 1. and 3. day after operation, before and 10 times after intake of 50 mg metoprolol.
Sudy is randomized into 3 groups: 1. Miniperfusion n.15 2. Perfusion n.15 3. offpump n.15
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •elective CABG patient -
排除标准
- •contraindication to metoprolol
研究组 & 干预措施
blood concentration of metoprolol
how does off-pump miniperfusion and perfusion CABG influence the absorption of metoprolol after CABG
干预措施: blood concentration of metoprolol (Drug)
结局指标
主要结局
absorbtion of the metoprolol
时间窗: one year
absorbtion of the metoprolol, blood samples are taken centrifuged, frozed and analyzed
次要结局
- atrial fibrillation(one year)