NCT04196738已完成不适用
Comparison of Volume Assist Control, Dual Mode and Airway Pressure Release Ventilation: A Physiological Study
University Hospital, Angers2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2020年6月30日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- change of PaO2 (mmHg)
研究概览
简要总结
The aim of the COMIX-R study is to assess the short term physiological effects of 3 ventilation strategies for adult patients with ARDS admitted to intensive care unit
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years or older
- •Invasive mechanical ventilation on tracheal probe
- •Acute respiratory distress syndrome, as defined by Berlin conference consensus, during hospitalization in intensive care,
- •Recovery phase of acute respiratory distress syndrome: spontaneous ventilation representing from 20 to 30% of ventilation in APRV mode.
- •No severe acidosis (pH> 7.30)
- •Patient affiliated to or beneficiary of a health care plan
- •Express consent of the patient or his/her SDM
排除标准
- •Pneumothorax
- •Contraindication to the insertion of a nasogastric tube with an esophageal balloon
- •Contraindication to the use of Electrical impedance tomography (pacemaker)
- •Pregnancy, lactating or parturient woman
结局指标
主要结局
change of PaO2 (mmHg)
时间窗: 15 minutes, 1 hour, 1hour and 45 minutes, 2 hour and 30 minutes
Arterial partial pressure of dioxygen Of note: As it is a physiological study, all the primary and secondary outcomes will be analyzed with the same importance.
次要结局
- -Tidal volume variability(15 minutes, 1 hour, 1hour and 45 minutes, 2 hour and 30 minutes)
- -Respiratory rate variability(15 minutes, 1 hour, 1hour and 45 minutes, 2 hour and 30 minutes)
- -Respiratory comfort(15 minutes, 1 hour, 1hour and 45 minutes, 2 hour and 30 minutes)
- -Pressure time product (PTP)(15 minutes, 1 hour, 1hour and 45 minutes, 2 hour and 30 minutes)
- MAP(15 minutes, 1 hour, 1hour and 45 minutes, 2 hour and 30 minutes)
- -Patient-ventilator asynchronies(15 minutes, 1 hour, 1hour and 45 minutes, 2 hour and 30 minutes)
- -expiratory and inspiratory transpulmonary pressure(15 minutes, 1 hour, 1hour and 45 minutes, 2 hour and 30 minutes)
- -ventilation distribution in the lungs(15 minutes, 1 hour, 1hour and 45 minutes, 2 hour and 30 minutes)
- -Work of breathing (WOB)(15 minutes, 1 hour, 1hour and 45 minutes, 2 hour and 30 minutes)
- -P0.1(15 minutes, 1 hour, 1hour and 45 minutes, 2 hour and 30 minutes)
- HR(15 minutes, 1 hour, 1hour and 45 minutes, 2 hour and 30 minutes)
- -other arterial parameters of hematosis(15 minutes, 1 hour, 1hour and 45 minutes, 2 hour and 30 minutes)
- -PEEPi(15 minutes, 1 hour, 1hour and 45 minutes, 2 hour and 30 minutes)
研究者
研究点 (2)
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