What is Behind Anemia in Systemic Lupus Erythematosus With Special Reference to Referactory Anemia
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 67
- 主要终点
- Causes of anemia
研究概览
简要总结
Systemic lupus erythroematosis (SLE) is a systemic autoimmune disease with multisystemic involvement. The condition has several phenotypes, with varying clinical presentations from mild mucocutaneous manifestations to multiorgan and severe central nervous system involvement. Several immunopathogenic pathways play a role in the development of SLE. Despite recent advances in technology and understanding of the pathological basis and risk factors for SLE, the exact pathogenesis is still not well known. Diagnosis of SLE can be challenging, and while several classification criteria have been posed, their utility in the clinical setting is still a matter of debate. Management of SLE is dictated by organ system involvement. Despite several agents shown to be efficacious in treating SLE, the disease still poses significant morbidity and mortality risks in patients[1].
Haematological abnormalities are common in systemic lupus erythroematosis. Anemia is found in about 50% of patients.
详细描述
Causes of anemia in SLE:
Anemia due to chronic disease is the most frequent in patients with SLE, representing approximately one-third of the cases [2].
Iron deficiency anemia is also a common cause, usually caused by blood loss (menorrhagia or gastrointestinal bleeding) [3].
Autoimmune hemolytic anemia (AIHA) a classification criteria for SLE [4]. The mechanism is thought to be caused by the destruction of red blood cells through warm or cold antibodies [5]. Patients with AIHA may present with symptoms of anemia or hemolysis or symptoms of an underlying disorder. Severe hemolysis may lead to hepatosplenomegaly, hemoglobinuria, and signs of heart failure [6]. Maanaging patients with AIHA may be challenging because specific therapy should be individualized in accordance with the disease manifestations and its severity [7].
Hemopoietic failure is the suspected to be the result of an immunologically damaged bone marrow (BM) .
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •-Adult patients (≥18 years) satisfying 2019 EULAR/ACR classification for systemic lupus erythroematosis[24].
- •Patients satisfying WHO criteria definition of anemia.
排除标准
- •Mixed connective tissue disorders.
- •Pregnancy .
结局指标
主要结局
Causes of anemia
时间窗: One week
Assess causes of anemia in SLE and which of them is most common in our locality
次要结局
未报告次要终点
研究者
Shymaa Saber
What is behind anemia in systemic lupus erythematosus with special reference to refractory anemia
Assiut University