Percutaneous Revascularization in Infarction With Late Presentation and Absence of Viability: Effects on Left Ventricular Remodeling and Contractility
试验速览
- 阶段
- 不适用
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Reverse myocardial remodeling after late recanalization in patients without viability
研究概览
简要总结
The purpose of this study is to evaluate whether late recanalization in patients with ST elevation myocardial infarction (STEMI) without Viability on Cardiovascular Magnetic Resonance Image (MRI) can reduce the reverse remodeling through the reduction of the End Systolic Volume (ESV) at 6 months.
详细描述
The purpose of this study is to evaluate whether late recanalization in patients with ST elevation myocardial infarction (STEMI) without Viability on Cardiovascular Magnetic Resonance can reduce the reverse remodeling through the reduction of the End Systolic Volume (ESV) at 6 months and through the improvement in segmental contractility of infarcted related artery at MRI.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
Optimized Medical Treatment (OMT)
The patient considered non-viable by MRI and randomized to Optimized Medical Treatment (OMT) will be treated according to Optimized Medical Treatment guidelines for Coronary Artery Disease (CAD)
干预措施: Optimized Medical Treatment (OMT) (Drug)
Angioplasty (PCI) and Optimized Medical Treatment (OMT)
The patient considered non-viable and randomized to Coronary Angioplasty will be treated with drug-eluting stent (PCI) and Optimized Medical Treatment (OMT)
干预措施: Optimized Medical Treatment (OMT) (Drug)
Angioplasty (PCI) and Optimized Medical Treatment (OMT)
The patient considered non-viable and randomized to Coronary Angioplasty will be treated with drug-eluting stent (PCI) and Optimized Medical Treatment (OMT)
干预措施: Drug Eluting Stent (DES) Coronary Angioplasty (Device)
结局指标
主要结局
Reverse myocardial remodeling after late recanalization in patients without viability
时间窗: 6 months
Evaluate reverse remodeling after late recanalization in patients without viability measuring End Systolic Volume (ESV) by MRI
次要结局
- Assessement of Myocardial contractility(6 months)
- Unplanned revascularization (Ischemia Driven and Not Ischemia Driven)(6 months)
- Stroke Event(6 months)
- Assessement of Left Ventricle Ejection Fraction (LVEF)(6 months)
- Cardiovascular Death(6 months)
- Evaluate Quality of Life(6 months)
- Acute MI Event(6 months)
- Cardiovascular-Related Hospitalization(6 months)
研究者
Barbara Porto Valente
Cardiology Physician
Instituto Dante Pazzanese de Cardiologia