Kidney and Pregnancy Registry
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 600
- 试验地点
- 1
- 主要终点
- Clinico-biological characteristics of patients
研究概览
简要总结
Maternal physiological adaptation to pregnancy plays an important role in the smooth progress of the pregnancy and the healthy growth of the fetus. This physiological adaptation takes place at the level of several organs, including the kidney. Physiological changes during a normal pregnancy take place at the anatomical, glomerular and tubular level.
In the event of pre-existing kidney damage (glomerular and tubular diseases, stone disease, high blood pressure (hypertension) etc...) these adaptations will not be optimal. This will have implications for:
- the course of the pregnancy with the occurrence of feto-maternal complications: miscarriages, pre-eclampsia, intrauterine growth retardation (IUGR), low birth weight, prematurity. The risk of feto-maternal complications increases with the degree of renal failure or with certain pathologies such as lupus.
- progression of kidney disease
Some maternal complications have long-term implications: preeclampsia is associated with a high risk of subsequent cardiovascular and renal complications. Pregnancies in these patients are high-risk pregnancies and require specialized management by an experienced group of gynecologists and nephrologists.
The creation of a retrospective and prospective register by collecting demographic, clinical, biological, radiological and genetic data concerning patients at each consultation within the CHU Brugmann Hospital will allow:
- to establish the epidemiological and clinico-biological characteristics of the patients followed at the Kidney and Pregnancy Clinic at the CHU Brugmann Hospital
- to analyze the risk factors for feto-maternal complications
- to analyze the risk factors for the occurrence of subsequent cardio-renal pathologies in patients who have had preeclampsia or an event during their pregnancy
- to identify patients who will need specialized genetic testing
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Pre-conception consultations
- •Woman of childbearing age with:
- •Renal damage (glomerular, tubular disease, renal lithiasis, systemic disease, metabolic diseases, congenital diseases, etc.)
- •Hematological disorders (sickle cell disease)
- •Kidney transplantation
- •High blood pressure (hypertension)
- •Pre-kidney transplant assessment in progress for discussion of contraception and pregnancy after kidney transplantation
- •Preeclampsia
- •Multiple miscarriages
- •IUGR and low birth weight in the fetus
- •Family history of kidney disease
- •Peri-gravid consultations
- •Pregnant women with
- •Pre-existing kidney damage
- •De novo renal failure (IR)
- •Proteinuria
- •Hematuria
- •Chronic hypertension
- •Pregnancy hypertension
- •Renal lithiasis
- •Postpartum consultations
- •Postpartum women with
- •Early/late pre-eclampsia
- •Eclampsia / Hemolysis Elevated Liver enzymes Low Platelet (HELLP) syndrome
- •Pregnancy hypertension
- •Postpartum hemorrhage
- •De novo renal failure postpartum
排除标准
- •Male patients Menopausal patients
结局指标
主要结局
Clinico-biological characteristics of patients
时间窗: 20 years
Risk factors for cardio-renal pathologies
时间窗: 20 years
Risk factors for the occurrence of subsequent cardio-renal pathologies in patients who had preeclampsia or an event during their pregnancy
Need for genetic testing
时间窗: 20 years
Identification of patients who will need specialized genetic testing
Risk factors for feto-maternal complications
时间窗: 20 years
Epidemiological characteristics of patients
时间窗: 20 years
次要结局
未报告次要终点
研究者
Tatiana Besse-Hammer
Head of clinical research unit
Brugmann University Hospital