Reduction of Dentine Hypersensitivity Using 8% Arginine Based Toothpaste and 8% Strontium Acetate Based Toothpaste: Randomized Controlled Clinical Trial
试验速览
- 阶段
- 不适用
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- reduction of dentin hypersensitivity
研究概览
简要总结
This is a randomized, triple-blind, placebo-controlled study. 51 subjects with a confirmed diagnosis of dentin hypersensitivity were randomized to one of three treatments: Arginine based toothpaste, strontium acetate based toothpaste , or placebo. Treatment will be done at baseline then patients will use the toothpaste at home twice per day by using soft bristled tooth brush and the given dentifrice using modified stillmans method as explained by examiner. Standard test stimuli is calibrated short blast of air syringe, will be applied to sensitive dentin surfaces. Subjects recorded the intensity of sensitivity in response to stimulus on a visual analog scale at baseline, and after 1 week, 2 weeks and 3 months.
详细描述
-
Study setting This study will be carried out on adult patients attending to the operative clinic in The Faculty of Oral and Dental Medicine, Cairo University, Egypt. The procedures will be carried out by postgraduate student esraa abdel ghaffar ahmed ali [B.D.S. 2012 from Misr International University] without an assistant.
-
Eligibility criteria
-
Inclusion criteria Normal adults will be recruited in this study, all the volunteers participated in this experiment will be healthy looking with free medical history.
Subjects aged between 18-35 years At least three sensitive teeth (buccal /facial) aspect with recession , abrasion, erosion with a score of >3 on verbal rating scale, ranging from 0-3= no pain/mild pain, 4-6= moderate pain, and 7- 10= severe pain. Subjects were required to be available for the duration of the study, and to sign an informed consent form
-Exclusion criteria Subjects with a history of allergy to any of the drugs or chemicals used in the study.
Any removable appliance (RPD or orthodontic retainer). Ongoing orthodontic treatment with fixed appliances.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
盲法说明
It will be a triple blinded study so that the participant, the researcher and the data analysis will be blinded.
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Normal adults will be recruited in this study, all the volunteers participated in this experiment will be healthy looking with free medical history.
- •Subjects aged between 18-35 years
- •At least three sensitive teeth (buccal /facial) aspect with recession , abrasion, erosion with a score of >3 on verbal rating scale, ranging from 0-3= no pain/mild pain, 4-6= moderate pain, and 7- 10= severe pain.
- •Subjects were required to be available for the duration of the study, and to sign an informed consent form
排除标准
- •Subjects with a history of allergy to any of the drugs or chemicals used in the study.
- •Any removable appliance (RPD or orthodontic retainer). Ongoing orthodontic treatment with fixed appliances.
- •Presence of any large or defective restorations, cracked enamel or caries on the hypersensitive tooth.
- •Pregnancy and lactating mothers.
- •Dental pathology causing pain similar to dentin hypersensitivity.
- •Patients with any systemic problem or mental or physical disability
结局指标
主要结局
reduction of dentin hypersensitivity
时间窗: 3 months
Subjects recorded the intensity of sensitivity in response to stimulus on a visual analog scale
次要结局
未报告次要终点
研究者
Esraa Abdel Ghaffar Ahmed Ali
Reduction of dentine hypersensitivity using 8% Arginine based toothpaste and 8% Strontium acetate based toothpaste: Randomized Controlled clinical trial
Cairo University