Telocytes in Umbilical Cord of Patients With and Without Pre-eclampsia
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Telocytes in placenta and umbilical cord
研究概览
简要总结
Studying the ultrastructural and immunohistochemical characteristics of Telocytes from umbilical cord vessels wall in PE patients compared to control and its relation to severity of disease whether controlled or uncontrolled.
详细描述
Patients fulfilling the eligibility criteria of the current research will be approached prior to delivery. The attending physician will explain the nature of the study and all patients will be asked to sign an informed consent.
Routine investigations will be performed to all patients including CBC, liver and renal function and urine analysis in addition to albumin creatinine ratio.
Ultrasound scanning including umbilical doppler indices measurement will be done for all cases before delivery using an HDI ultrasound system (AlbiniouTL Ultrasound, Bothell, WA, USA).
Non stress test is routinely done for all hypertensive patients twice weekly as part of routine work up of such patients in our emergency unit using (CTG machine-NSL BT-350 Bistos) (Korea).
Diagnosis of chronic hypertension, gestational hypertension and preeclampsia
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Study group Singleton pregnancies complicated with hypertension undergoing pre-labour CS at gestational age (34+0 to 40+0). These will be divided into 3 groups according to the type of disease either chronic hypertension (Group A), gestational hypertension (Group B) or preeclampsia (Group C).
- •Control group Singleton pregnancies undergoing elective pre-labour CS that are otherwise healthy.
排除标准
- •Women with history of medical co-morbidities other than hypertension were excluded from the study. This includes the following: Renal diseases, autoimmune diseases, history of organ transplantation and immunosuppressive therapy, hematological diseases, history of thrombotic events, cardiopulmonary diseases, liver diseases, Acute and chronic inflammatory diseases.
- •Pregnancy induced medical disorders like: Gestational thrombocytopenia.
- •Multiple pregnancies.
- •Abnormal placentation, i.e. Placenta previa and Morbidly adherent placenta.
- •Fetal anomalies.
- •vaginal deliveries and CS in labour.
结局指标
主要结局
Telocytes in placenta and umbilical cord
时间窗: Immediately after delivery of the placenta during cesarian section of pregnancies with gestational age (34-40) weeks
The number and distribution of Telocytes by immunohistochemistry in placenta and umbilical cord vessels wall.
次要结局
- Telocytes Morphology in relation to disease severity(Immediately after delivery of the placenta during cesarian section of pregnancies with gestational age (34-40) weeks)
研究者
Hatem Awaga
Lecturer of Obstetrics and Gynecology
Sohag University