Identifying the impact of peripheral and respiratory muscle training on metaboreflex and cardiac outcomes in heart failure

Curtin University0 个研究点目标入组 180 人开始时间: 2020年8月17日最近更新: 2020年8月31日

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•New York Heart Association (NYHA) functional class II-III outpatients will be screened to meet the following inclusion criteria: For heart failure with reduced ejection fraction (HFrEF) - i) history of ischemic or dilated cardiomyopathy, duration of HF symptoms >1 year, ii) stable symptoms > 3 months, iii) left ventricular ejection fraction less than, or equal to 35%, iv) at least one prior hospitalisation due to chronic heart failure (CHF). Patients with chronic heart failure with preserved ejection fraction (HFpEF), as defined by the Framingham criteria with ejection fraction (EF) greater than, or equal to 50% will be included if they have diastolic dysfunction determined by echocardiography (grade equal to, or greater than 1) and sinus rhythm. Healthy participants, with no prior cardiovascular disease, metabolic disease or severe condition limiting exercise capacity (such as moderate to severe respiratory conditions, neurological or musculoskeletal impairments) will be included as matched control participants (for age and sex).

•Significant valvular or pericardial disease, infiltrative or hypertrophic cardiomyopathy, cor pulmonale, significant pulmonary disease, and peripheral vascular disease.

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