Comparison Of Bubble CPAP (Variable Flow CPAP) Vs Pressure Sources Of CPAP In Preterm Infants An Open Labelled Randomized Controlled Trial.

Respiratory distress syndrome (RDS) is the most common pulmonary aliment in preterm newborns, and the incidence may reach up to 80 per cent in the extreme preterm populations (less than 28 weeks). With the antenatal corticosteroid in preterm pregnancy, early onset respiratory distress in preterm newborns is supported with continuous positive airway pressure support (CPAP) which has gained popularity due to its low cost, non- invasive respiratory support. Following the widespread adoption of these interventions over the past several decades, the principle from of respiratory support for preterm infants with or at risk of RDS has moved from mechanical ventilation via an endotracheal tube to non- invasive ventilation. However, given the level of certainty about the effect of bubble CPAP versus other pressure sources on the risk of treatment failure and most associated morbidity and mortality for preterm infants, further trials are needed to provide evidence of sufficient validity and practice. This trial aims at comparing the two common varieties of CPAP for their clinical outcomes as the primary mode of respiratory therapy.