NCT06475768已完成不适用
The Influence of Menopausal Status on Myocardial Stiffness and Exercise Capacity Among Female Masters Endurance Athletes.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- Myocardial stiffness
研究概览
简要总结
The purpose of this research is to study postmenopausal female masters athletes to see if they will show greater myocardial stiffness and reduced exercise capacity than premenopausal females and similarly aged male masters athletes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Longstanding history of competitive endurance athletic performance defined as >15 years of continuous athletic training for at least 7 hours per week and ongoing engagement in competitive events.
排除标准
- •A current or prior diagnosis of cardiovascular disease as defined by the presence of structural heart disease, heart failure, symptomatic coronary artery disease, more than moderate valve disease or prior valve surgery,
- •Current or recent pregnancy within 1 year
- •Positive pregnancy test (study visit 1)
- •Concurrent or use within 1 year of oral contraceptives or hormone replacement therapy,
- •Unable to undergo a cMRI (Please refer standard clinical contraindications for MRI)
结局指标
主要结局
Myocardial stiffness
时间窗: Day 14
Myocardial stiffness will be measured by magnetic resonance elastography (kPa)
次要结局
- Left ventricular filling pressures with exercise(Baseline)
- Exercise capacity(Baseline)
研究者
Kathryn F. Larson
Senior Associate Consultant, Cardiovascular Medicine
Mayo Clinic
研究点 (1)
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