Tumor-Associated Macrophages Correlate With Response and Outcomes in Advanced Non-Small Cell Lung Cancer After First Line Treatment.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 107
- 试验地点
- 2
- 主要终点
- Response to treatment of advanced NSCLC with high or low TAM.
研究概览
简要总结
The purpose of this study is to investigate the effects of tumor associated macrophage (TAM) in advanced non-small cell lung cancer (NSCLC) patients on the treatment response and outcome of these subjects. Pathologic specimens from tissue bank will be stained by immunostaining methods with CD68 antibody. The clinical treatment response and outcomes will be analyzed between high or low TAM.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •advanced NSCLC,
- •more than 20 years old,
- •measurable tumor,
- •response and outcome recorded after the first line treatment.
排除标准
- •Early stage NSCLC,
- •less than 20 years,
- •pregnancy,
- •unmeasurable NSCLC.
结局指标
主要结局
Response to treatment of advanced NSCLC with high or low TAM.
时间窗: 2-3 months
All patients with advanced non-small cell lung cancer (NSCLC) who had been treated were included. The decision of advanced NSCLC treatment was a consensus by the patient and clinician, and approved by team conference (including the oncologists, pulmonologists, pathologists, radiologists, surgeons, radiation oncologists, and nuclear medicine specialists). The tumor response was evaluated using computerized tomography according to the Response Evaluation Criteria in Solid Tumors (RECIST). The treatment response of advanced between high and low TAM patients were compared.
次要结局
- Outcomes of advanced NSCLC with high and low TAM.(12-24 months)
研究者
Chung Fu-Tsai
Chang Gung Memorial Hospital
Chang Gung Memorial Hospital