The effects of probiotic supplementation on intestinal permeability, inflammatory factors and clinical status in pediatrics with severe sepsis: a randomized double blind clinical trial

Tehran University of Medical Sciences0 个研究点目标入组 44 人开始时间: 待定最近更新: 2023年8月21日

适应症

试验速览

暂无简介。

•Aged 1-12 years old
•Diagnosis of severe sepsis according to pediatric sepsis consensus conference 2005 criteria in children admitted to PIC

•PICU admission more than 72 hours
•Ileus, overt gastrointestinal bleeding, anatomic obstruction of the gastrointestinal tract (eg, volvulus, intestinal atresia), recent esophageal or gastrointestinal surgery
•Gastrointestinal diseases such as celiac disease, inflammatory bowel disease (IBD), short bowel syndrome (SBS), irritable bowel syndrome (IBS)
•Use of feeding routes leading to jejunum such as jejunostomy
•Probiotic use one month before entering the study
•Use of steroids and other immunosuppressive drugs
•Suffering from immunosuppressive diseases such as malignant tumors, acquired immunodeficiency syndrome, etc.
•Severe acute malnutrition (According to the World Health Organization: Z-Score weight for height/length and BMI less than -3 SD average child growth standards WHO

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