Respiratory Microbiome in COPD. Relationship With Systemic and Pulmonary Inmune Response.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Relationship of pulmonary microbiome with the immune response (local and systemic).
研究概览
简要总结
Hypothesis:
COPD patients with frequent exacerbations have different pulmonary and systemic immune response than COPD patients without frequent exacerbations and this is related to their microbiome.
详细描述
The objective of this project is to determine the pulmonary microbiome and its relationship with the pulmonary and systemic inmune response in COPD patients with frequent (FE) and non frequent exacerbations (NE).
- The pulmonary immune response.
-The role of mucins, antimicrobial peptides (AMPs), Matrix metalloproteinases (MMPs) and Toll-like receptors (TLRs) as lung defense mechanisms and their possible relationship with the microbiome in COPD and FE patients. 2. The systemic immune response. -The pulmonary and blood inflammatory response and circulating bacterial products as markers of the systemic immune response.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Diagnosis of COPD according to national and international guidelines.
- •Clinical stability (8 previous weeks).
- •Signature of informed consent.
排除标准
- •Antibiotic treatment the previous 8 weeks.
- •Other lung diseases.
- •Active neoplasic disease.
- •Terminal concomitant disease.
结局指标
主要结局
Relationship of pulmonary microbiome with the immune response (local and systemic).
时间窗: 6 months
Microbiome will be determined by using 16s RNA techniques. The inmune response will be studied with ELISA kits.
次要结局
未报告次要终点