The Relationship Between the Nreural Drive and Intrinsic Positive End-expiratory Pressure of the Chronic Obstructive Pulmonary Disease Patients With Respiratory Failure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- neural respiratory drive assessed by the root mean square of diaphragm electromyogram (EMGdi) of the chronic obstructive pulmonary disease patients with respiratory failure
研究概览
简要总结
To investigate the relation the nreural drive and intrinsic positive end-expiratory pressure(PEEPi) of the chronic obstructive pulmonary disease(COPD) patients with respiratory failure.In present study the PEEPi of COPD patients was increased by increasing the resistance of the respiratory system, the change of the neural drive was recorded.
详细描述
To investigate the relation the nreural drive and intrinsic positive end-expiratory pressure(PEEPi) of the chronic obstructive pulmonary disease(COPD) patients with respiratory failure.The diaphragm electromyogram (EMGdi) represents the neural drive to the diaphragm.A multi-pair esophageal electrode catheter was used to record the EMGdi.The PEEPi was assessed by the by the balloon-catheter in the multi-pair esophageal electrode catheter. In present study the PEEPi of COPD patients was increased by increasing the resistance of the respiratory system, the change of the neural drive( EMGdi) was obtained from the a multi-pair esophageal electrode catheter All the signal recorded in the computer. The relation the nreural drive assessed by EMGdi and intrinsic positive end-expiratory pressure(PEEPi) would be analysed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •chronic obstructive pulmonary disease patients with respiratory failure
排除标准
- •Heart failure
- •cardiac dysrhythmia
- •Loss of consciousness
研究组 & 干预措施
neural respiratory drive
neural respiratory drive assessed by EMGdi recorded from a multipair esophageal electrode
干预措施: Resistance of the respiratory system (Other)
结局指标
主要结局
neural respiratory drive assessed by the root mean square of diaphragm electromyogram (EMGdi) of the chronic obstructive pulmonary disease patients with respiratory failure
时间窗: 1 hour
neural respiratory drive assessed by the root mean square of diaphragm electromyogram (EMGdi) obtained from the a multi-pair esophageal electrode catheter
次要结局
未报告次要终点
研究者
Zhang Jianheng
Clinical Professor
The First Affiliated Hospital of Guangzhou Medical University