7.0T Magnetic Resonance Imaging Study for Hepatic Encephalopathy
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Functional connectivity and structural alterations between individuals with different subtypes of HE and healthy subjects.
研究概览
简要总结
This clinical trial study aims to detect the imaging characteristics of patients with hepatic encephalopathy (HE) using 7-Tesla (7T) magnetic resonance imaging (MRI).
详细描述
In this study, we analyzed the imaging characteristics of HE. First, with the advantages of 7TMRI, we analyzed the differences in imaging characteristics between HE patients and the healthy, including brain functional imaging and structural imaging. Second, we analyzed the differences in imaging characteristics between different subgroups of HE patients. Finally, we analyzed the correlation between the prognostic results of HE patients after follow-up and the imaging characteristics.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 89 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with clinical suspected or diagnosed hepatic encephalopathy according to relevant guidelines.The patient's education level is above primary school level.
- •Regular follow-up.
排除标准
- •Contraindications to MRI.
- •Patients with cerebrovascular disease, brain tumors, epilepsy, other neurodegenerative disease.
结局指标
主要结局
Functional connectivity and structural alterations between individuals with different subtypes of HE and healthy subjects.
时间窗: 5 years
Functional connectivity calculation is mainly based on the BOLD sequence, which is used to describe the degree of connectivity between different brain regions and reflect the functional activity of the brain. Gray matter (GM) morphological destruction, cortical thickness, and subcortical nuclear volume in patients with hepatic encephalopathy were analyzed based on structural magnetic resonance imaging（sMRI）.
次要结局
- Correlation between spectral features of clinical variables and spectral features of imaging.(5 years)
研究者
Xin Lou
Deputy Director of Department of Radiology
Chinese PLA General Hospital