NCT01793428已完成不适用
Predictive Abilities for Transfusion Needs of Capillary Lactate Measure in Emergency for Injured Normotensive Patients
University Hospital, Grenoble1 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2011年8月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Transfusion of 6 or more units of packed Red Blood Cells (RBC)
研究概览
简要总结
13% of injured normotensive patients arriving in emergency unit need mass blood-transfusion of six or more units of packed Red Blood Cells. It is currently difficult to predict the need for such a mass blood-transfusion. Indeed hemoglobin point of care testing (hemocue) and blood pressure can be normal during the first hours despite intensive bleeding.
It's well known that blood or arterial lactate measures correlate with trauma severity but these measures are not available in a pre-hospital setting. The investigators want to test whether capillary lactate measures also correlate with trauma severity and can therefore predicts earlier transfusion needs.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult admitted in vital emergency unit
- •Severe trauma
- •normotensive (Systolic Blood Pressure >90mmHg)
- •patient subjected to capillary haemoglobin and glucose measurements
- •patient beneficiary of social security
排除标准
- •pregnant woman
- •liver deficiency
- •pre-hospital transfusion
- •hypothermia below 35°C
- •protected persons according to the law
- •Nor epinephrine > 0.1gamma/kg/min
结局指标
主要结局
Transfusion of 6 or more units of packed Red Blood Cells (RBC)
时间窗: 48 hours
次要结局
- injury scores (ISS,SOFA)(24h)
- arterial lactate measures(upon arrival at the vital emergency unit)
- blood lactate measure(upon arrival at vital emergency unit)
- Intensity of medical care(upon arrival at vital emergency unit)
- Bleeding Predictive Score(upon arrival at vital emergency unit)
- Mortality(28 days)
- transfusion of 4 units of packed RBC(48 hours)
研究者
研究点 (1)
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