NCT02917616已完成不适用
The Effect of Drinking-Water pH on the Human Gut Microbiota
The Novo Nordisk Foundation Center for Basic Metabolic Research0 个研究点目标入组 30 人开始时间: 2015年11月1日最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 主要终点
- Shannon's alpha diversity index
研究概览
简要总结
This study evaluates the effect of alkaline (pH=9) versus neutral (pH=9) drinking-water on the gut microbiota of healthy male volunteers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Non-smoker
- •Age 18 - 35 years
- •Weight stabile for at least 2 months
- •BMI between 20.0 - 27.0 kg/m^2
排除标准
- •Habitual consumption of caloric or artificially sweetened beverages in excess of 1L/week
- •Habitual average consumption of alcohol in excess of 7 drinks/week
- •Antibiotic treatment within two months of inclusion
- •Chronic or acute illness
- •Previous abdominal surgery
研究组 & 干预措施
Alkaline water
Experimental
Two liters (minimum) daily of alkaline drinking-water (pH=9) for 14 days
干预措施: Alkaline drinking-water (Other)
Neutral Water
Active Comparator
Two liters (minimum) daily of neutral drinking-water (pH=7) for 14 days
干预措施: Neutral drinking-water (Other)
结局指标
主要结局
Shannon's alpha diversity index
时间窗: Intervention day 14
Diversity of the gut microbial community
次要结局
- Bray-Curtis(Intervention day 14)
- Estimated richness(Intervention day 14)
- Serum insulin; global(Intervention day 14)
- Simpsons' reciprocal diversity index(Intervention day 14)
- Unweighted UniFrac(Intervention day 14)
- Operational taxonomic unit(Intervention day 14)
- Plasma glucose; individual timepoints(Intervention day 14)
- Observed richness(Intervention day 14)
- Weighted UniFrac(Intervention day 14)
- Bacterial genera(Intervention day 14)
- High sensitivity C-reactive protein(Intervention day 14)
- Plasma glucose; global(Intervention day 14)
- Serum insulin; individual timepoints(Intervention day 14)
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