Lipoprotein Effects of Substituting Beef Protein for Carbohydrate
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 67
- 试验地点
- 2
- 主要终点
- Total Cholesterol
研究概览
简要总结
The purpose of this study is to test whether replacing dietary carbohydrate with protein, using beef as the primarily source of protein, will improve risk factors for cardiovascular disease.
详细描述
The primary aim of this study is to test the hypothesis that replacing dietary carbohydrate with protein, using beef as the primarily source of protein, will have beneficial effects on components of atherogenic dyslipidemia and postprandial lipoprotein response and that these effects will be independent of saturated fat intake.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Blood pressure less than 150/90
- •Body mass index (BMI)≥ 20 and ≤ 35 kg/m2
- •Non-smoker
- •Agrees not to consume alcohol during the study
- •Agrees to abstain from taking dietary supplements during the study
- •LDL-cholesterol and total cholesterol < 95th percentile for age and sex
- •Fasting triglycerides < 500 mg/dL
- •Fasting glucose concentration < 126 mg/dL
- •Hematocrit (HCT) ≥ 36%
- •At least three months of a weight-stable state (± 3% of body weight)
排除标准
- •Personal history of coronary heart disease, cerebrovascular disease, peripheral vascular disease, diabetes, lung disease, bleeding disorder, liver or renal disease, HIV or of cancer (other than skin cancer) in the last five years
- •Taking drugs known to affect lipid metabolism or insulin resistance, hormones, or the blood thinning agent warfarin
- •Abnormal thyroid stimulating hormone (TSH)
- •Strength trains with resistance weights more than four hours per week
结局指标
主要结局
Total Cholesterol
时间窗: 3 weeks, 8 weeks, and 13 weeks
Non-HDL Cholesterol
时间窗: 3 weeks, 8 weeks, and 13 weeks
Apolipoprotein B
时间窗: 3 weeks, 8 weeks, and 13 weeks
LDL-Cholesterol/HDL-Cholesterol
时间窗: 3 weeks, 8 weeks, and 13 weeks
Apolipoprotein B/Apolipoprotein AI
时间窗: 3 weeks, 8 weeks, and 13 weeks
次要结局
- LDL subclass 3 (LDL3)(3 weeks, 8 weeks, and 13 weeks)
- LDL peak diameter(3 weeks, 8 weeks, and 13 weeks)
- HDL subclass 2 (HDL2)(3 weeks, 8 weeks, and 13 weeks)