Comparison of the Non-invasive CNAP Pulse Pressure Variation With the Invasive Gold Standard
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- Cardiac output
研究概览
简要总结
Noninvasive pulse pressure variation for the guidance of perioperative fluid therapy is compared with the gold standard of invasive measurements. Cardiac output is derived by the PICCO monitor.
Hypothesis: Noninvasive CNAP PPV predicts fluid responsiveness. A grey zone for the prediction of fluid responsiveness will be defined.
详细描述
Accuracy of PPV measured by two devices,PICCO and CNAP, is compared with the manually calculated PPV from the arterial line waveform. Established tests like passive leg raising and end-expiratory occlusion are used for prediction of fluid responsiveness. Intraoperative events like volume challenge are monitored.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •major surgery
- •need for invasive arterial measurements
排除标准
- •age under 18
- •cardiac dysrhythmia
- •vascular pathology at punction site
结局指标
主要结局
Cardiac output
时间窗: 1, 2, 5, 10, 15 and 20 minutes after volume challange and
Improvement of cardiac output dependent on PPV before volume challenge
次要结局
未报告次要终点
研究者
Dr. Jochen Renner
PD Dr. med. Jochen Renner
University Hospital Schleswig-Holstein