Exploring the Potential for 18F-fluoro-ethyl-tyrosine (18F-FET) to Enable Wider Access to Molecular Imaging for Patients With Pituitary Adenomas (FET-pit-PET Study)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Maximum Standardized Uptake Values (SUVmax) over pituitary tumour on each of 11C-methionine and 18F-fluoroethyltyrosine PET scans
研究概览
简要总结
The goal of this single centre pilot study is to explore whether 18F-fluoro-ethyl-tyrosine PET (FET-PET) yields comparable findings to 11C-methionine PET (Met-PET) for the localisation of pituitary tumours.
详细描述
Up to 20 patients with pituitary adenomas (PA) who have previously undergone 11C-methionine PET (Met-PET) as part of routine clinical care will undergo 18F-fluoroethyltyrosine PET (FET-PET). Patients with newly diagnosed PA or residual/recurrent pituitary tumours following previous treatment will be eligible for recruitment to the study.
Quantitative and qualitative analyses will be performed to assess whether MET-PET and FET-PET yield comparable findings in patients with newly diagnosed or recurrent PA.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Participant is willing and able to give informed consent for participation in the study
- •Male or female, age 18 or above
- •Presence of pituitary adenoma suspected on the basis of clinical/biochemical and/or radiological findings
- •Previous 11C-Met-PET/CT
排除标准
- •Inability to give informed consent
- •Pregnancy or suspected pregnancy
- •Inability to lie supine for 30-60 minutes
- •Patient body habitus above scanner dimensions
- •Known allergy to intravenous radiographic contrast agents
研究组 & 干预措施
Study cohort
All patient's enrolled in the study will undergo an 18F-FET-PET
干预措施: 18F-Fluoro-ethyl-tyrosine (FET) PET (Diagnostic Test)
结局指标
主要结局
Maximum Standardized Uptake Values (SUVmax) over pituitary tumour on each of 11C-methionine and 18F-fluoroethyltyrosine PET scans
时间窗: 1 day
Comparison of maximum Standardized Uptake Values (SUVmax) measured over pituitary tumours on each type of PET scan.
次要结局
- Maximum Standardized Uptake Values (SUVmax) over normal pituitary gland and parasellar structures (e.g. cavernous sinuses) on each of 11C-methionine and 18F-fluoroethyltyrosine PET scans(1 day)
研究者
Professor Mark Gurnell
Professor of Clinical Endocrinology
University of Cambridge