Myocardial performance Index forprediction of an outcome in septic shock patients: A prospective observational cohortstudy

Sepsis induced cardiac dysfunction is well known complication in patients with septic shock, with Incidence rate around 40-50%and associated with high mortality. Multiple invasive parameters(SVR,CO/CI, by TPTD, flow trac,etc)serum Biomarkers- procalcitonin, NT proBNP, cardiac troponins (I & T), CRP etc and non invasive parameters( ECHO for systolic and diastolic dysfunction)used to predict severity and outcome. All parameters have some limitations; none of these are accurate independent predictors. A new ECHO parameter, myocardial performance index which indicates both systolic and diastolic function of the heart and is independent of heart rate, preload and afterload conditions of the heart, so it can be more correlated with sepsis induced cardiomyopathy changes. Previous studies have compared serum biomarkers with either systolic/diastolic dysfunction or ejection fraction in septic shock patients. MPI as a non-invasive and quick bedside measure can equally or more superiorly be used to predict the 28 day mortality. And we assume that MPI can be correlated well with Serum Trop-I and NTproBNP.