Blood Outgrowth Endothelial Cells (BOECs) and Megakaryocytes (MKs) for in vitro studies of hemostatic and secretory function. - Cellular function in BOECs and MKs

Erasmus MC, Universitair Medisch Centrum Rotterdam0 个研究点目标入组 700 人开始时间: 待定最近更新: 2024年7月8日

适应症

试验速览

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•In order to be eligible to participate in this study, a subject must meet all
•of the following criteria:
•Prior diagnosis of VWD, low VWF, inherited platelet function defects,
•bleeding of unknown cause or genetic disorders in which dysfunction of the
•secretory pathway has been implicated in disease pathogenesis.
•For patients >=16 years old; written informed consent
•For patients 12-15 years old; written informed consent from both the patient
•and their parent(s)/legal guardian(s)
•For patients <12 years old; written informed consent from their
•parent(s)/legal guardian(s)
•Family members
•Age 18 years or older
•Family member of a patient with VWD, low VWF, inherited platelet function
•defects, bleeding of unknown cause or genetic disorders in which dysfunction of
•the secretory pathway has been implicated in disease pathogenesis.
•Family members may or may not be affected.
•Healthy controls
•Age 18 years or older
•Not previously diagnosed with VWD, low VWF, inherited platelet function
•defects, bleeding of unknown cause or genetic disorders in which dysfunction of
•the secretory pathway has been implicated in disease pathogenesis.

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