The Effects of Epinephrine and Cortisol on Emotion in Depression
试验速览
- 阶段
- 早期 1 期
- 状态
- 撤回
- 主要终点
- Sadness-induced subgenual cingulate activity as measured by functional magnetic resonance imaging
研究概览
简要总结
This study investigates the effects of two hormones called epinephrine and cortisol on how the brain processes emotional material using functional MRI to measure brain activity. The study hopes to learn how epinephrine and cortisol affect the brain differently in depressed and non-depressed individuals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 21 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Weight of less than 280 pounds
- •HAM-D Score of greater than 7 for depression participants
排除标准
- •Psychotropic medications
- •Recent surgery
- •Endocrine disorders
- •Liver disease
- •Kidney disease
- •Thyroid disorder
- •History of malaria
- •Tuberculosis
- •Osteoporosis
- •Glaucoma or cataracts
- •Chronic expressed infections (herpes, HIV, etc)
- •History of congestive heart failure
- •History of recurring seizures
- •Stomach ulcers
- •Comorbid psychosis
- •Current use of illicit drugs
- •Any cardiovascular disease (angina, hypovolemia, coronary artery disease, low/high blood pressure, etc)
- •Any pulmonary disease
- •Any cerebrovascular disease
- •Sulfate hypersensitivity
- •Infection
- •Pregnancy
- •Parkinson's Disease
- •Panic Disorder
- •Over 280 pounds in weight
- •In-dwelling ferrous metals
- •Left handed
- •Abnormal hearing
- •Claustrophobic
- •Head injury with loss of consciousness
- •Active suicidal ideation
研究组 & 干预措施
Healthy Arm, CORT + EPI, then PLB + EPI
Healthy participant will receive cortisol pill and epinephrine infusion
干预措施: Hydrocortisone Acetate (CORT) (Drug)
Healthy Arm, CORT + EPI, then PLB + EPI
Healthy participant will receive cortisol pill and epinephrine infusion
干预措施: Epinephrine Sulfate (EPI) (Drug)
Healthy Arm, PLB + EPI, then CORT + EPI
Healthy participant will receive placebo pill and epinephrine infusion
干预措施: Epinephrine Sulfate (EPI) (Drug)
Healthy Arm, PLB + EPI, then CORT + EPI
Healthy participant will receive placebo pill and epinephrine infusion
干预措施: Placebo (PLB) (Drug)
Depression Arm, CORT + EPI, then PLB + EPI
Depressed participant will receive cortisol pill and epinephrine infusion
干预措施: Hydrocortisone Acetate (CORT) (Drug)
Depression Arm, CORT + EPI, then PLB + EPI
Depressed participant will receive cortisol pill and epinephrine infusion
干预措施: Epinephrine Sulfate (EPI) (Drug)
Depression Arm, PLB + EPI, then CORT + EPI
Depressed participant will receive placebo pill and epinephrine infusion
干预措施: Epinephrine Sulfate (EPI) (Drug)
Depression Arm, PLB + EPI, then CORT + EPI
Depressed participant will receive placebo pill and epinephrine infusion
干预措施: Placebo (PLB) (Drug)
结局指标
主要结局
Sadness-induced subgenual cingulate activity as measured by functional magnetic resonance imaging
时间窗: 2 hours
次要结局
未报告次要终点