Association of Hyperuricemia and Non Alcoholic Fatty Liver Disease and Liver Fibrosis Risk in Adult Obese Patients
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 111
- 主要终点
- Prevalence of NAFLD
研究概览
简要总结
- Identifying the association between hyperuricemia and NAFLD can lead to early detection and prevention of liver fibrosis in adult obese patients.
- Understanding the relationship between hyperuricemia and NAFLD can inform targeted therapy, such as urate-lowering treatment, to potentially slow disease progression.
3 - To examine the relationship between serum uric acid levels and liver fibrosis severity*: Assessing the correlation between serum uric acid levels and the severity of liver fibrosis in adult obese patients with NAFLD.
4- To identify potential mechanisms underlying the association*: Exploring the potential mechanisms by which hyperuricemia may contribute to the development and progression of NAFLD and liver fibrosis in adult obese patients.
详细描述
Hyperuricemia is associated with nonalcoholic fatty liver disease (NAFLD), whereas whether the association differed by hyperuricemia onset age remained unclear. This study sought to investigate the associations of hyperuricemia onset age with the risk of incident NAFLD across adulthood.
Obesity has been demonstrated to show a consistent link with the increased possibility of nonalcoholic fatty liver disease (NAFLD). Since both serum uric acid (SUA) and obesity are essential components of metabolic syndrome (MetS), it is uncertain whether the incidence of NAFLD results from serum uric acid, obesity, or other potential factors based on previous studies.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age: Adults (typically 18-65 years old)
- •2 - Body Mass Index (BMI): Obese patients with a BMI ≥ 30 kg/m²
- •3- Hyperuricemia : Elevated serum uric acid levels (typically > 7 mg/dL for men and > 6 mg/dL for women)
排除标准
- •excessive alcohol consumption ( > 20 gm /day in men and 10 in g /day in women )
- •2- use of steatogenic within the past 6 months
- •3- positive test for hepatitis B surface antigen and hepatitis B core antibody
- •4- Drug induced liver injury and autoimmune hepatitis
- •5 - cirrhosis and other causes of liver disease
结局指标
主要结局
Prevalence of NAFLD
时间窗: 1 year
The proportion of adult obese patients with NAFLD in the study population
次要结局
- Serum uric acid level(1 year)
研究者
Aya Adel Mahmoud Abu Shady
Internal medicine Resident doctor
Assiut University