Virtual Rehabilitation for the Treatment of Motivational Deficits in Schizophrenia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Apathy Evaluation Scale (AES)
研究概览
简要总结
The loss of motivation has emerged as a critical symptom in schizophrenia that is consistently linked to functional disability for affected individuals. Despite advances in treatment, there have not emerged any effective treatments for this loss of motivation, which ultimately hinders our ability to promote recovery for individuals with schizophrenia. To address this critical unmet therapeutic need, this study aims to investigate a novel computerized motivation rehabilitation program using virtual reality to treat motivation loss in schizophrenia.
详细描述
Motivational deficits have emerged as a critical determinant of functional disability in schizophrenia (SZ). Despite significant advances in our understanding and treatment of the illness, effective therapeutic strategies for motivational deficits have remained elusive. This has ultimately hindered our ability to promote recovery for individuals with SZ so that they can return to their premorbid level of functioning. An emerging therapeutic approach in SZ has utilized computerized remediation strategies, with recent efforts focused on cognitive deficits. To date, however, such a therapeutic strategy has not been developed for the critical motivational deficits in SZ. In light of the detrimental functional consequences of motivational deficits in SZ, there is a clear need for effective therapeutic strategies for the treatment of these motivational deficits experienced by affected individuals. To address this unmet therapeutic need, this pilot therapeutic trial will investigate the efficacy of a novel virtual reality-based motivation rehabilitation program in schizophrenia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Between 18 and 35 years old;
- •DSM-IV diagnosis of Schizophrenia or Schizoaffective Disorder;
- •Outpatients on a stable dose of antipsychotic and other psychotropic medications for the preceding 4 weeks;
- •Minimum Apathy Evaluation Scale (AES) score of 34.
排除标准
- •Diagnosis of other DSM-IV Axis I disorders;
- •History of active substance abuse or dependence in the past 6 months, with the exception of nicotine;
- •History of neurological disease;
- •History of head trauma with loss of consciousness >30 minutes
- •Presence of significant akathisia (a rating of >2 on the Barnes Akathisia Rating Scale (BARS) Global item); or
- •Presence of significant extrapyramidal symptoms (a rating of >2 on >2 items of the Simpson Angus Rating Scale (SARS))
- •Any MRI contraindications.
研究组 & 干预措施
VR Motivation Training
Weekly training sessions with a VR motivation treatment 1 hour per week for 8 weeks.
干预措施: VR Motivation Training (Behavioral)
结局指标
主要结局
Apathy Evaluation Scale (AES)
时间窗: 9 weeks
次要结局
- Calgary Depression Scale for Schizophrenia (CDSS)(9 weeks)
- Simulator Sickness Questionnaire (SSQ)(9 weeks)
- Scale for the Assessment of Negative Symptoms (SANS)(9 weeks)
- Scale for the Assessment of Positive Symptoms (SAPS)(9 weeks)
- Quality of Life Scale (QLS)(9 weeks)
- Brief Assessment of Cognition in Schizophrenia (BACS)(9 weeks)
- Functional Brain Imaging(9 weeks)
- Structural Brain Imaging(9 weeks)
研究者
George Foussias
Clinician Scientist
Centre for Addiction and Mental Health