Acute Effect of Transcutaneous Electrical Nerve Stimulation on the Sympathetic and Parasympathetic Systems in Individuals With Heart Failure
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- differences in blood levels of catecholamines differences in blood levels of catecholamines differences in blood levels of catecholamines Differences in blood levels of catecholamines
研究概览
简要总结
The purpose of this study is to determine acute effect the transctutaneous electrical nerve stimulation in sympathetic and parassympathetic system in individuals with heart failure.
详细描述
Heart failure (HF) is the inability of the heart to maintain adequate levels of blood supply to tissues. In recent years there has been an increased prevalence of heart failure (HF), in Brazil there are about two million people diagnosed with HF and 240,000 new cases per year. Thus, the IC constitutes the most serious problem now and in the fields of cardiology and public health. Sympathetic activity is increased and correlates with a worse prognosis and survival in these patients. Currently, the pharmacological blockade of the sympathetic system by chronic use of beta-blockers are commonly used to treat hyperactivity, but these interventions have side effects. The transcutaneous electrical nerve stimulation (TENS) has been used successfully to control pain in different clinical conditions and may be a noninvasive strategy to reduce drug and not the severity of increased sympathetic.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Possess stable heart failure grade II or III according to NYHA;
- •Ejection fraction <40% determined by echocardiography;
- •Having no change in drug therapy one month before being included in the study;
- •There have been Myocardial Infarction (AMI) three months before study entry;
排除标准
- •Patients with grade IV heart failure according to NYHA;
- •Acute respiratory;
- •Unstable angina;
- •Ventricular arrhythmia, unstable until three months before the start of the study;
- •Pacemaker;
- •Active smoking;
- •Diabetes mellitus;
- •And fever or infectious disease.
研究组 & 干预措施
tens
干预措施: transcutaneous electrical nerve stimulation (Other)
结局指标
主要结局
differences in blood levels of catecholamines differences in blood levels of catecholamines differences in blood levels of catecholamines Differences in blood levels of catecholamines
时间窗: one minute before and after transutaneous electrical nerve stimulation intervention (acute effect)
For evaluation of catecholamines (epinephrine, norepinephrine and dopamine) will be held one antecubital venipuncture and collected into tubes containing ethylenediaminetetraacetic acid (EDTA).
次要结局
- improvement of heart rate variability(one minute before and after transcutaneous electrical nerve stimulation intervention (acute effect))