Comparative study between intubate surfactant administration and extubate (INSURE) vs lesser invasive surfactant administration(LISA) technique for delivery of surfactant in newborn with respiratory distress syndrome

Pushpender Singh Mehra0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•1)Preterm 28-36 weeks
•2)Requirement of nasal continues airway pressure(ncpap) level beyond or equal to 5cm of water and fiO2 greater or equal to o. 30 to maintain sPO2 of 88-92%.
•3)Requirement of nasal high flow nasal canula(NHHHFNC) level beyond or equal to 5L/min cm of water and fiO2 greater or equal to 0.3 to maintain sPO2 of 88-92%.
•4)Requirement of free flow O2 to 2L/min cm of water and fiO2 greater or equal to 0.3 to maintain sPO2 of 88-92%.

•1)Severe respiratory distress syndrome with high oxygen requirement and or severe respiratory acidocissuch that ventilatory support will be necessary after surfactant therapy, suggested FiO2 threshold at which intubation for surfactant will be considered is >60(lower threshold)
•2)Pulmonary hypoplasia
•3)Cyanotic heart disease
•4)Antinatally diagnosed congenital lung anomalies
•5)Requirement intubation for resuscitation at birth

发起方

Pushpender Singh Mehra