Prevalence and Risk Factors of Arterial Insufficiency in Patients With HIV / AIDS
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 206
- 试验地点
- 1
- 主要终点
- Arterial insufficiency
研究概览
简要总结
The purpose of this study is to determine the risk factors associated with the occurrence of arterial insufficiency in patients with HIV / AIDS, and to identify the prevalence of this disease. The estimated prevalence is 10%, similar to that reported in the general population.
详细描述
A case study nested in a cohort of patients with HIV / AIDS at Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, with a cohort of 1500 patients , a sample size of 206 individuals was calculated. Data collection was performed in a prospective cross shape.
During the interview, written informed consent for inclusion in the study, along with a standard query of vascular surgery in which the patient's history as well as cardiovascular risk factors. Also, a vascular physical examination including palpation of pulses in upper and lower extremities (brachial, radial, ulnar, femoral, popliteal, posterior tibial and dorsalis pedis), femoral murmurs search and determining ankle / brachial indexes with a standardized method.
In determining the ABI was counted with a Doppler ultrasound 8 mHz, transducer gel and a sleeve for manual measurement of blood pressure, 20% longer than the largest diameter of the arm circumference.
If the patient is diagnosed with, symptomatic or asymptomatic arterial insufficiency, ABI measurements were performed at rest and effort, plus pressure index finger-arm or plethysmography. Patients with altered rates were followed in vascular surgery care.
The data were recorded in a single database unique protected by password. The results were analyzed using the statistical program STATA v 9.0.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 89 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with HIV / AIDS are included in active consultation of Infectious Diseases INCMNSZ and sign informed consent.
排除标准
- •Patients who do not wish to participate in the study and those who did not complete their interview and vascular physical examination.
结局指标
主要结局
Arterial insufficiency
时间窗: 1 time
Arterial insufficiency is measured by Ankle / brachial index described as ABI\<0.9 or ABI \>1.2
次要结局
- Smoking(1 time)
- Age(1 time)
- Gender(1 time)
- Diabetes mellitus(1 time)
- Hypercholesterolemia(1 time)
- Hypertriglyceridemia(1 time)
- Hypoalphalipoproteinemia(1 time)
- Stroke(1 time)
- Drug abuse(1 time)
- Viral Load(1 time)
- CD4(1 time)
- HAART (Highly active anti-retroviral therapy)(1 time)
- Smoking index(1 time)
- Hypertension (High blood pressure)(1 time)
- Ischemic heart disease(1 time)
- AIDS(1 time)
- Diagnostic Time of HIV(1 time)
- Time HAART(1 TIME)
研究者
Carlos Hinojosa
subdirector of clinical research
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran