The Effects of Atorvastatin on the Occurrence of Postoperative Atrial Fibrillation After Off-Pump Coronary Artery Bypass Grafting Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 124
- 试验地点
- 1
- 主要终点
- the development of postoperative in-hospital atrial fibrillation confirmed by 12-lead ECG
研究概览
简要总结
The purpose of this study is to determine whether pretreatment with atorvastatin protects against atrial fibrillation following off-pump coronary artery bypass graft surgery.
详细描述
Atrial fibrillation after cardiac surgery is the most common arrhythmic complication that may increase incidence of congestive heart failure, renal insufficiency, and stroke, which increase the length of hospital stay, the rates of re-hospitalization, and cost of care. Its pathogenesis is multifactorial, and its prevention and management remain suboptimal. Recently, observational evidence has suggested that patients who have undergone previous statin therapy have a lower incidence of postoperative atrial fibrillation.
The purpose of this study is to determine whether pretreatment with atorvastatin protects against atrial fibrillation following off-pump coronary artery bypass graft surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •consecutive patients scheduled for the elective off-pump CABG surgery
排除标准
- •prior statin use
- •previous episodes of atrial fibrillation
- •impaired renal function with serum creatinine >2mg/dL
- •serum aspartate aminotransferase or alanine aminotransferase concentrations more than 3 times the upper limit of normal
- •a malignancy or inflammatory disease
研究组 & 干预措施
1
Atorvastatin group
干预措施: atorvastatin (Drug)
结局指标
主要结局
the development of postoperative in-hospital atrial fibrillation confirmed by 12-lead ECG
时间窗: in-hospital period
次要结局
- major adverse cardiac and cerebrovascular events rate, including cardiovascular death, postoperative stroke, myocardial infarction, or persistent atrial fibrillation,and identification of predictive markers for postoperative atrial fibrillation(30 days)