NCT04961125招募中不适用
Multicenter Study on the Pathogenic Germline Gene Variants of Colorectal Polyposis in China
Second Affiliated Hospital, School of Medicine, Zhejiang University5 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2021年8月2日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 5
- 主要终点
- germline variant detection rate in the polyposis population
研究概览
简要总结
Patients suspected of adenomatous polyposis were included. The criteria used were more than 10 polyps observed under colonoscopy, and pathological confirmation of adenoma. Clinical data and pedigree information were collected. The variants of 139 genes associated with different hereditary cancers and polyposis were screened by NGS, which was performed by Genetron Health on the HiSeqX-ten sequencing platform.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •clinical diagnosis of adenomatous polyposis;
- •enough samples (provide at least 5ml of peripheral whole blood) for germline variant detection
排除标准
- •genetic diagnosis of polyposis syndrome
结局指标
主要结局
germline variant detection rate in the polyposis population
时间窗: through study completion, an average of 3 years
germline variant detection rate in the polyposis population
次要结局
未报告次要终点
研究者
研究点 (5)
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