NCT00559442已完成不适用
Susceptibility to High Altitude Pulmonary Edema in Subjects With Increased Pulmonary Artery Pressure During Exercise in Normoxia and at Rest in Hypoxia
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Frequency of HAPE after rapid ascent to 4559 m
研究概览
简要总结
It has been shown, that subjects susceptible to high altitude pulmonary edema (HAPE)are characterized by an abnormal increase of pulmonary artery pressure at rest in hypoxia and during exercise in normoxia. This abnormal rise of pulmonary artery pressure has also been observed in about 10 % of otherwise healthy subjects without prior altitude exposure. The aim of the study is to investigate the susceptibility to HAPE in unacclimatized subjects with abnormal increase of pulmonary artery pressure at rest in hypoxia and during exercise in normoxia after rapid ascent to high altitude (4559 m).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •abnormal increase of pulmonary artery pressure at rest in hypoxia and during exercise in normoxia
- •ability to climb Margherita Hut
排除标准
- •Birth at or above 1500 m altitude
- •any cardiovascular or pulmonary disease
- •Infection disease
- •Intake of drugs, in particular Acetazolamide, Nifedipine, corticosteroids or PDE-5-inhibitors.
- •Pregnancy
结局指标
主要结局
Frequency of HAPE after rapid ascent to 4559 m
时间窗: during the 48 h stay at altitude
次要结局
- Time course of pulmonary artery pressure(during the 48 h stay at altitude)
- Assessment of right ventricular function by echocardiography(during the 48 h stay at altitude)
研究者
研究点 (2)
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