Effects of Exercise and 5-HTP on Cortisol Levels
试验速览
- 阶段
- 不适用
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Change in plasma cortisol from baseline to 20 minutes post
研究概览
简要总结
It has been shown that 5-HTP stimulates cortisol levels in plasma and saliva. Similarly, it has been shown that intense exercise stimulates an increase in plasma and salivary cortisol levels. The purpose of this study is to examine the combined effects of 5-HTP + intense exercise on plasma and salivary cortisol levels.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy men and women, not taking medication known to alter glucocorticoid metabolism
排除标准
- •Hypertension
- •Coronary artery disease
- •Psychiatric disorders
- •Any disease preventing them from participating in intense exercise
- •Subjects taking medication known to interfere with glucocorticoid metabolism will be excluded
结局指标
主要结局
Change in plasma cortisol from baseline to 20 minutes post
时间窗: baseline, 20 min
Plasma cortisol will be assessed at baseline and 20 min post exercise and compared to baseline, and compared between treatments: 5-HTP vs placebo visit. The interventions are acute ( 1 dose, 1 day), for 5-HTP and for placebo, there is no follow up. The interventions are at least 1 week apart. For a given subject, the estimated time for study completion for the 2 treatments is 10 to 30 days
次要结局
- Change in plasma cortisol from baseline to 5 minutes post(baseline, 5 minutes)