Clinical Application of Cytokine Adsorption Technology in AIDS Patients With Severe Pneumonia and/or Septic Shock: An Observational Study.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Mortality rate
研究概览
简要总结
Observing the Real-World Application Effectiveness of Cytokine Immune Adsorption Technology in AIDS Patients with Severe Pneumonia or septic shock.
详细描述
This is a prospective, single-center, non-randomized, clinical observational cohort study primarily focused on observing the clinical effects of cytokine adsorption technology in patients with AIDS complicated by severe pneumonia and/or septic shock. Based on the real-world application of cytokine adsorption technology in AIDS patients with severe pneumonia or septic shock, the study divides patients into two groups: one receiving cytokine adsorption combined with standard treatment, and another receiving standard treatment only. The study aims to observe the impact of these two different treatment strategies on clinical outcomes.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Confirmed HIV infection;
- •Progression to AIDS stage: CD4+ count <200 cells/ul and/or occurrence of AIDS opportunistic infections;
- •Age between 18 and 65 years;
- •Meeting the diagnosis of severe pneumonia or septic shock:
- •The criteria for severe pneumonia diagnosis refer to the 2021 ATS (American Thoracic Society) and IDSA (Infectious Diseases Society of America) guidelines for the treatment of community-acquired pneumonia;
- •The criteria for septic shock refer to the Chinese Society of Critical Care Medicine's "Chinese Guidelines for the Emergency Treatment of Sepsis/Septic Shock (2018).
排除标准
- •Coexisting central nervous system lesions, severe liver disease, or cirrhosis;
- •Concurrent AIDS-related or unrelated tumors;
- •Women who are pregnant or breastfeeding;
- •Severe underlying diseases of the heart, lungs, liver, kidneys, etc.;
- •Alcohol abuse or drug use;
- •The researcher believes that the overall condition of the subject affects the evaluation and completion of the trial.
结局指标
主要结局
Mortality rate
时间窗: 4 weeks
Compare the mortality rates of the cytokine adsorption combined with standard treatment group and the standard treatment group.
次要结局
- Improvement in critical care scoring(Baseline and during treatment at weeks 1, 2, 3, 4.)
研究者
Linghua LI
Chief physician
Guangzhou 8th People's Hospital