Investigations on the Effect of Kale on the Lipid Status (Untersuchungen Zum Einfluss Von Grünkohl Auf Den Lipidstatus)
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Change of lipid status parameters
研究概览
简要总结
This intervention study investigates the effects of various kale preparations (dietary supplements) on lipid status parameters. Within the study period of 8 weeks, three blood withdrawals are planned (week 0, 4 and 8) for the volunteers. Lipid status parameters (total cholesterol, HDL cholesterol, LDL cholesterol, triacylglycerides) will be determined in blood. There is a correlation between contents of LDL cholesterol, total cholesterol and triacylglycerides and the risk for cardiovascular diseases (CVD). In contrast, a high content of HDL cholesterol is correlated with a lower risk for CVD. In addition, the contents of apolipoprotein A1 and apolipoprotein B will be analysed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •total cholesterol > 200 mg/dl
排除标准
- •LDL cholesterol < 130 mg/dl
- •medication to lower blood lipids
- •genetically based hypercholesterolemia
研究组 & 干预措施
Kale Powder
5 capsules with kale preparation "kale powder" per day for 8 weeks
干预措施: Kale Preparation "Kale Powder" (Dietary Supplement)
Kale Extract
5 capsules with kale preparation "kale extract" per day for 8 weeks
干预措施: Kale Preparation "Kale Extract" (Dietary Supplement)
Flavonoid Extract
5 capsules with kale preparation "flavonoid extract" (from kale) per day for 8 weeks
干预措施: Kale Preparation "Flavonoid Extract" (Dietary Supplement)
Placebo
5 capsules with "placebo" per day for 8 weeks
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
Change of lipid status parameters
时间窗: weeks 0, 4 and 8
total cholesterol, HDL cholesterol, LDL cholesterol
次要结局
- Change of apolipoproteins(weeks 0, 4 and 8)
- Change of antioxidant capacity(weeks 0, 4 and 8)
研究者
Volker Boehm
Head of Bioactive Plant Products Research Group
University of Jena