跳至主要内容
临床试验/CTRI/2025/05/086180
CTRI/2025/05/086180尚未招募不适用

A Comparative Clinical Study To Evaluate The Effect Of Marichanjana And Darvadyanjana In The Management Of Arma With Special Reference to Pterygium

Dr Divya Tukaram Moodi1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2025年5月5日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
40
试验地点
1
主要终点
2 Length

研究概览

简要总结

Armais one among Shuklagataroga explained by Acharya Sushrutha and Acharya Vagbhata. It is defined as IYARTI GACCHATHI ITI ARMA. Which means gradually spreading of fleshy growth occurring in Shukla mandala. The Lakshanas of Arma can be correlated with signs and symptoms of Pterygium in modern ophthalmology. Pterygium is a wing shaped fold of conjunctiva encroaching upon cornea from either side within interpalpebral fissure. Pathologically Pterygium is an elastotic degeneration of subconjunctival tissue. In a population-based study from rural central India, prevalence of pterygium increased from 6.7±0.8% in the age group from 30–39 years to 25.3±2.1% in the age group of 70–79 years. The epidemiological studies around worldwide have shown that prevalence rates ranges from 0.3% to 37.46%.

Pterygium is more common in people living in hot climate, and in those who work outdoors. Thus it is considered as a response to prolonged effect of environmental factors such as exposure to sunlight (UV rays), dry heat, high wind and abundance of dust. Asymptomatic nature of the disease and non-availability of medical treatment are the main hurdles in management. Meanwhile it fails to decrease the complication such as development of cyst, ongoing diplopia, Dry eye, scleral or corneal melting. it not only affects the outlook of the patient, but also affects refractive astigmatism which can have significant impact on vision in advanced stage due to the invasion of cornea.

In modern science surgical treatment is only satisfactory approach. Recurrence after surgical excision is common and recurred lesions grow more aggressively than primary lesions. Cost of Surgery is too expensive. Hence to overcome the lacuna in modern therapeutics the present clinical study has been taken up. Therefore an alternative treatment which is safe, devoid of complication, easy to administer and cost effective is need for hour.

In Classics different treatment modalities are explained for the management of Arma mainly Lekhana, Chedhana, Anjana. Arma is a type of Mamsavriddhi (muscle like growth) hence Acharyas have indicated as Chedana sadya and Lekhana sadya vyadhi. Marichanjanaand Darvadyanjanaboth are mentioned in Basavarajeeyam, Netraroghadhikara. Hence an attempt is made to compare the efficacy of Marichanjana and Darvadyanjana in management of ARMA

NULL HYPOTHESIS

H0 - Marichanjana is not effective in management of Arma with special reference to   pterygium.

ALTERNATE HYPOTHESIS

H1 - Marichanjana Is more effective than Darvadyanjana i in management Arma with special reference to pterygium

H2 - Marichanjana is less effective than Darvadyanjana in management of Arma with special reference to pterygium.

研究设计

研究类型
Interventional
分配方式
Coin toss, Lottery, toss of dice, shuffling cards etc
盲法
Open Label

入排标准

年龄范围
30.00 Year(s) 至 70.00 Year(s)(—)
性别
All

入选标准

  • •1 Patients between age group of 30 years to 70 years.
  • •2 Clinical features as per classics.
  • •3 Patients with Pterygium that is limited to limbus.
  • •4 Controlled Diabetic patients 5 Controlled HTN Patients.

排除标准

  • •1 Arma with any other ocular pathology.
  • •2 Pseudo pterygium 3 Those contraindicated for Anjana karma.
  • •4 Pregnant women and Lactating mother.

结局指标

主要结局

2 Length

时间窗: 60 Days

1 Pictorial presentation

时间窗: 60 Days

3 Thickness

时间窗: 60 Days

次要结局

  • 1 Foriegn body sensation(2 Redness)

研究者

发起方
Dr Divya Tukaram Moodi
申办方类型
Other [self]

研究点 (1)

Loading locations...

相似试验