Dissecting Human Immune Responses To Infection With Influenza or SARS-CoV-2

Washington University School of Medicine1 个研究点分布在 1 个国家目标入组 300 人开始时间: 2025年3月7日最近更新: 2026年3月12日

适应症

干预措施

试验速览

阶段: 不适用
状态: 招募中
发起方: Washington University School of Medicine
入组人数: 300
试验地点: 1
主要终点: To measure the difference in the concentration of systemic and mucosal influenza-specific or SARS-CoV-2-specific IgG and IgA in the blood, saliva, nasopharynx, and lower airways and how these concentrations change over time following acute infection

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

The purpose of this study is to evaluate the virus-specific immune response in people who are symptomatic with confirmed influenza or COVID-19. We will study the immune response of people who have and who have not been vaccinated with the seasonal influenza and COVID-19 vaccines within the past year. All participants will have data collected and blood, saliva, and nasal swabs performed at five separate visits; 1) at study enrollment, 2) on study day 7, 3) on or between study days 10 to 28, 4) on study day 90, and 5) on study day 180. For participants who agree to the optional sub-study, bronchoscopy with bronchoalveolar lavage (BAL) and endobronchial biopsy (EBBx) will be performed once between study days 10 and 28 and once at study day 180. As part of the bronchoscopy procedure, two chest x-rays will be performed. The bronchoscopy and chest x-ray procedures are not required for participation in the study.

研究设计

研究类型: Observational
观察模型: Cohort
时间视角: Prospective

入排标准

年龄范围: 18 Years 至 60 Years（Adult）
性别: All
接受健康志愿者: 是

入选标准

•Participants must have presented with acute, symptomatic seasonal influenza or SARS-CoV-2 infection proven by an approved CLIA certified test and be enrolled in study while still symptomatic or within 72 hours of the resolution of viral respiratory illness symptoms.
•Alternatively, uninfected participants in the control cohort must have received an FDA-approved seasonal influenza and/or SARS-CoV-2 vaccine within the past 12 months and not experienced a documented influenza or SARS-CoV-2 infection since receiving that most recent vaccine dose.
•Participants must be able to understand and provide full written informed consent.
•Participants must be male or female between the ages of 18 and
•Participants must be in stable health, as determined by medical history and targeted physical exam related to that history.

排除标准

•Co-infection with any respiratory virus in addition to the index influenza or SARS-CoV-2 infection on a multi-plex viral testing panel.
•Severe illness with anticipated need for hospitalization for the index infection.
•Current or previous diagnosis of an immunocompromising condition.
•Receipt of systemic immunosuppressants or immune-modifying drugs for > 14 days in total within 6 months prior to screening or is anticipating the need for immunosuppressive treatment at any time during study participation.
•Current symptomatic acute or unstable chronic disease requiring medical or surgical care, to include significant change in therapy or hospitalization, at the discretion of the investigator. Any known diagnosed chronic pulmonary, cardiovascular, renal, hepatic, hematologic, or metabolic disorder with the exception of isolated treated hypertension.
•Known chronic neurologic or neurodevelopmental condition including spinal cord injury with resultant weakness of any kind (this does not exclude patients with chronic back pain or previous disk herniation/back surgery, only patients with documented weakness, quadriplegia or paraplegia). This exclusion criterion does not exclude from the study individuals with recurrent migraine headaches as their only chronic neurologic condition.
•Active cancer diagnosis, including any cancer that has not been in remission for at least 1 year. Isolated basal or squamous cell skin cancers are not excluded.
•History of excessive alcohol consumption, drug abuse, psychiatric conditions, social conditions, or occupational conditions that in the opinion of the investigator would preclude compliance with the study.
•Body Mass Index (BMI) > 40
•Pregnant women and nursing mothers or women who are planning to become pregnant during the study interval.
•Have donated blood, blood products or bone marrow within 30 days before study entry or plan to donate blood at any time during the duration of study participation or up to 30 days after the last study blood draw.
•Current ongoing participation in a clinical trial evaluating an investigational agent, unless the trial is in follow-up only and the last dose of the investigational agent was taken > 30 days or > 5 half-lives prior to enrollment, whichever is greater.
•Any condition in the opinion of the investigator that would interfere with the safe and proper conduct of the study.
•For participants willing to undergo bronchoscopy:
•Coagulopathy as defined by screening safety labs that reveal an INR > 1.4, at PTT > 40, or a platelet count < 100,000 precludes participation in the bronchoscopy procedure.
•Evidence of ongoing significant pulmonary disease on the day of bronchoscopy, including pulse oximetry with oxygen saturation of 92% or less on room air, or infiltrate or pleural effusion noted on an upright PA and lateral chest x-ray performed on the day of bronchoscopy.
•Allergy or contraindication to anesthesia for participants willing to undergo bronchoscopy.

研究组 & 干预措施

Uninfected Cohort

Subjects that have received an FDA-approved seasonal influenza and/or SARS-CoV-2 vaccine within the past 12 months and not experienced a documented influenza or SARS-CoV-2 infection since receiving the vaccine dose.