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临床试验/NCT03017976
NCT03017976Unknown不适用

Swan Study: Swimming Pool Environment Impact on the Human Respiratory Health

Universidade do Porto1 个研究点 分布在 1 个国家目标入组 1,000 人开始时间: 2017年1月最近更新:
适应症

试验速览

阶段
不适用
入组人数
1,000
试验地点
1
主要终点
Spirometry with bronchodilation

研究概览

简要总结

This study aims to assess the influence of exposure to swimming pool environment on respiratory symptoms and diseases, and on cancer outcomes among swimmers and swimming pool attendants.

详细描述

Objectives:

  1. In relation to human exposure 1.1. To assess the levels of certain disinfection by-products (DBPs) in blood and urine (biomarkers of exposure); 1.2. To assess swimming induced changes in biomarkers of genotoxicity, specifically micronuclei (MN) in exfoliated urothelial cells and buccal cells and DNA damage in peripheral blood lymphocytes, urine mutagenicity and in exfoliated urothelial; 1.3. To assess the effects of swimming pool exposure on oxidative stress and lung damage in swimming pool users; 1.4. To assess the impact of DBPs, including volatile DBPs on airway function, inflammation and reactivity; 1.5. To assess the impact of swimming on skin transepidermal water loss and dermal condition.
  2. In relation to swimming pool environment 2.1. To assess water and air quality through the analysis of several chemical (DBPs and other), physicochemical and microbiological parameters and the associated short-term variation of their levels (hourly and daily); 2.2. To assess microbiological contamination of highly used surfaces; 2.3. To assess mutagenicity of indoor chlorinated and brominated swimming pool water.

Methods

Study setting Chlorinated and brominated public indoor municipal swimming pools in the North of Portugal.

Study design

研究设计

研究类型
Observational
观察模型
Case Crossover
时间视角
Cross Sectional

入排标准

年龄范围
12 Years 至 —(Child, Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • 未提供

排除标准

  • 未提供

结局指标

主要结局

Spirometry with bronchodilation

时间窗: First week after recruitment

Volatile organic compounds in the exhaled breath condensate

时间窗: First week after recruitment

Airway resistance measurement

时间窗: First week after recruitment

Airway reactance measurement

时间窗: First week after recruitment

Fractional concentration of orally exhaled nitric oxide

时间窗: First week after recruitment

次要结局

  • Diagnosis of immunoglobulin E (IgE) mediated allergies by skin prick testing(First week after recruitment)
  • Autonomic nervous system function assessment by pupillometry(First week after recruitment)
  • Transepidermal water loss(First week after recruitment)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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