Phosphorus Absorption in Healthy Adults and in Patients With Moderate Chronic Kidney Disease
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Fractional Phosphorus Absorption
研究概览
简要总结
Chronic kidney disease (CKD) affects approximately 26 million Americans with many more at risk for disease development. Elevated serum phosphorus (P) and related abnormalities in P homeostasis due to progressive loss of kidney function are primary driving forces behind cardiovascular dysfunction and mortality in CKD patients. Intestinal P absorption is an critical aspect in P homeostasis but has been understudied, particularly in the early stages of CKD progression. This study aims to determine P absorption in patients with moderate CKD compared to healthy adults.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Fractional Phosphorus Absorption
时间窗: Measured from serial blood draws over a 4-hour time frame
Radiophosphorus (P-33) activity determined by liquid scintillation counting in serum and urine after oral and IV administration will be used to determine fractional phosphate absorption.
次要结局
- Serum 1,25(OH)2D(Measured from baseline measures and serial blood draws over a 4-hour time frame)
- Serum FGF23(Measured from baseline measures and serial blood draws over a 4-hour time frame)
- 24h Urine phosphate(measured from two, 24-hour urine collections)
- Serum phosphate(Measured from baseline measures and serial blood draws over a 4-hour time frame)
- Serum parathyroid hormone (PTH)(Measured from baseline measures and serial blood draws over a 4-hour time frame)
研究者
Kathleen Hill Gallant
Principal Investigator
Purdue University